Ferroptosis is a non-apoptotic type of cell death that is induced by uncontrolled iron-dependent phospholipid peroxidation and has important roles in disease. This Expert Recommendation article summarizes ferroptosis regulation and mechanisms and provides recommendations to increase the reproducibility and robustness of ferroptosis research.

The tumour suppressor p53 controls non-apoptotic cell death (NACD) pathways, including ferroptosis, necroptosis and pyroptosis. This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.

Repair of DNA double-strand breaks requires chromatin opening; however, the mechanisms involved were unclear. This work shows that sequential histone deamidation and acetylation modifications induce chromatin decompaction by reducing positive charge at the DNA–nucleosome interface.

A distinct population of adipose progenitor cells contributes to the accumulation of visceral white adipose tissue in middle-aged male mice.

A 2012 study discovered that RNA–binding proteins are more numerous and diverse than previously thought, many having non-canonical RNA-binding domains.

Pia Cosma recounts the development of STORM, which was the first microscopy method to break the diffraction limit of light.

Evandro De-Souza discusses an article by Dillin and Taylor that revealed the importance of neurons in organism-wide stress responses and the role of such cell-nonautonomous stress responses in ageing.

A study that helped explain how lack of sequence conservation can go hand in hand with functional conservation.