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In vivo ligation of clinically used therapeutic antibodies via bioorthogonal click chemistry to antibody–drug conjugates leads to enhanced antitumour activity in heterogeneous and treatment-resistant tumours.
Naked mole-rat (Heterocephalus glaber) queens produce isopropyl myristate, a low-volatility ester that high-ranking animals detect and avoid, which alters prolactin and progesterone in other females to suppress reproduction and preserve eusocial hierarchy.
Satellite imagery and machine learning used for the mapping of six seminatural open wetland types and land-use disturbance in European countries shows that wetlands are highly fragmented and have uneven restoration needs.
A 54-qubit realization of non-Abelian S3 topological order demonstrates that combining anyon braiding with fusion enables universal topological quantum computation.
Scenario simulations using global economic models show that by 2050 the transformation of food systems towards healthy diets, improved productivity and halving of food waste result in a restructuring of global agriculture.
A new class of materials, quantum statistical plasmonic metacrystals, is described, which can selectively transmit different types of light based only on their quantum coherence, showing bands of allowed and forbidden photon statistics.
A molten salt, high-pressure synthesis method enables solution-based production of diverse refractory metal nitride nanocrystals, expanding access to technologically important nitride materials for advanced applications.
A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.
Elastic instabilities in mechanical metamaterials can be harnessed to programme fracture behaviour, transforming instability from a failure mechanism into a design principle that increases fracture energy by up to tenfold.
The saturation of geomagnetic activity with solar wind strength can be explained by a regression to the mean effect, suggesting that the impact of extreme geomagnetic storms can be twice as large as previously thought
Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve the properties of thiopurine chemotherapeutic drugs.
A database of daily dust metals in Europe is established and a machine learning model shows that transported dust intrusion events over the past decade are linked to changes in atmospheric circulation, while an ice core shows that the increase in dust since pre-industrial times is governed by increasing aridity in North Africa..
Large-scale behavioural studies show that people approach a new game systematically and adaptively rationally. A cognitive model called the ‘Intuitive Gamer’ offers insights into this process and may inform the design of more flexible AI systems.
Single-nucleus RNA-seq and ATAC-seq analyses on post-mortem brain samples from African American, Latin and white individuals identify cell-type-specific molecular signatures that are associated with cognitive impairment and/or Alzheimer’s disease across diverse population groups.
A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketogenic diet-mediated intestinal tumorigenesis, highlighting the need for nuanced consideration of dietary strategies for cancer prevention.
A rich variety of both integer and fractional high-Chern insulators are observed in a moiré system composed of Bernal bilayer graphene and rhombohedral tetralayer graphene.
