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All cell types found in the body are derived from stem cells. However, genetic mutations can impact the ability of stem cells to develop into fully functional cells. Also, as the body ages, the number of endogenously occurring stem cells reduces, diminishing the capacity for the body to replace missing or dysfunctional cell types. Stem cell therapies aim to use stem cells, or products and cells derived from them, to repair tissues that are not functioning correctly because of damage, disease or abnormal development.
This Collection welcomes submissions that explore the therapeutic potential of stem cells or describe the use of stem cells and stem cell-derived products to treat human disease. We welcome submission of studies providing basic molecular and cellular insights into stem cell biology, preclinical and clinical studies, and studies that improve the production of human stem cell therapies.
This is a joint Collection across Nature Medicine, Nature Communications, Communications Medicine, Communications Biology and Scientific Reports. We encourage authors to choose which journal to submit to according to their own preference. However, before deciding which journal to submit to, the relevant journal webpages should be checked to ensure the submission is within scope for the journal. Each journal will apply its standard editorial criteria for scope and advance. Where submissions are more suitable for another participating journal, editors will recommend submission to a more appropriate alternative journal. Note that Nature Communications and Scientific Reports will only consider original research Articles.
Circadian medicine, or chronotherapy, seeks to improve drug efficacy based on individuals’ circadian rhythms. Here, the authors combine principles of tissue engineering and synthetic biology to create a chronogenetic gene circuit for cell-based delivery of biologic drugs at controlled times of day.
Shortages of donor blood for transfusions can have severe medical consequences, and ex vivo production of red blood cells offers a potential solution. Here authors developed synthetic EPO receptors, which allow erythropoiesis (red blood cell production) without the need for expensive EPO.
Ishida et al. transplant Crispr/Cas9 gene edited MHC-II knockout or wild-type retinal pigment epithelium into cynomolgus monkey eyes. MHC-II knockout RPE engraft successfully with no infiltration of inflammatory cells.
Low-frequency sinusoidal electromagnetic fields enhance osteogenesis in mice by regulating the miR34b-5p/STAC2 axis, providing insights into potential osteoporosis treatments.
Jaspers et al. investigate whether plasma VLCFA-lipid levels are associated with disease severity in both male and female patients with X-linked adrenoleukodystrophy (ALD). Lipidomic analyses reveal a profound impact of ALD on the lipidome and provide potential biomarkers for predicting clinical outcomes in ALD patients.
Takahashi et al. intravenously inject human Muse cells into model mice with Stanford type B acute aortic dissection. This effectively reduces diameter expansion rates, mortality and has a greater therapeutic effect than intravenous injection of large amounts of human mesenchymal stem cells.
Dystrophic Epidermolysis Bullosa is an uncurable monogenetic skin disease. Here, Neumayer et al. develop a cGMP-compatible CRISPR- and iPS cell-based approach that produces gene-corrected, autologous skin composite grafts for definitive treatment.
Sustained safety outcomes were seen at 2-year follow-up after induced pluripotent stem cell-derived mesenchymal stromal cell infusion in 15 individuals with steroid-resistant acute graft-versus-host disease.
Neurointestinal diseases cause significant morbidity and effective treatments are lacking. Here, authors perform autologous cell transplantation of enteric neural stem cells in a mouse model of colonic aganglionosis and report restoration of colonic contractile activity.
The generation of primary organoids, from fetal fluid-derived epithelial stem or progenitor cells, offers the possibility of modeling different developing tissues during gestation, even beyond the limits of pregnancy termination.