S1PR1

Sphingosine-1-phosphate receptor 1
Structure of SIPR1-lysozyme fusion (lysozyme as backbone trace) PDB 3v2y
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3V2W, 3V2Y
Identifiers
Symbols	S1PR1; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1
External IDs	OMIM: 601974 MGI: 1096355 HomoloGene: 1071 IUPHAR: S1P1 ChEMBL: 4333 GeneCards: S1PR1 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • sphingosine-1-phosphate receptor activity • sphingolipid binding Cellular component • plasma membrane • external side of plasma membrane • integral to membrane Biological process • angiogenesis • cell adhesion • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • brain development • transmission of nerve impulse • regulation of cell adhesion • neuron differentiation • positive regulation of cell migration • positive regulation of Ras GTPase activity • endothelial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • positive regulation of positive chemotaxis • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of stress fiber assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1901	13609
Ensembl	ENSG00000170989	ENSMUSG00000045092
UniProt	P21453	O08530
RefSeq (mRNA)	NM_001400.4	NM_007901.5
RefSeq (protein)	NP_001391.2	NP_031927.2
Location (UCSC)	Chr 1: 101.7 – 101.71 Mb	Chr 3: 115.71 – 115.72 Mb
PubMed search	[1]	[2]

S1PR1 (sphingosine-1-phosphate receptor 1) also known as S1P₁ or EDG1 (endothelial differentiation gene 1) is a protein that in humans is encoded by the S1PR1 gene. S1P₁ is a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Function

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell–cell adhesion.

See also

• Lysophospholipid receptor

Interactions

S1PR1 has been shown to interact with 5-HT1A receptor, GNAI1 and GNAI3.

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
• Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 476–9. PMID 11915345.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.
• Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.". J. Biochem. 131 (6): 767–71. PMID 12038970.
• Wang D, Zhao Z, Caperell-Grant A,et al. (2008). "S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.". Mol Cancer Ther 7 (7): 1993–2002. PMID 18645009.
• Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.
• Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.". J. Biol. Chem. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733.
• Lee MJ, Van Brocklyn JR, Thangada S, et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.". Science 279 (5356): 1552–5. doi:10.1126/science.279.5356.1552. PMID 9488656.
• Lee MJ, Thangada S, Liu CH, et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist.". J. Biol. Chem. 273 (34): 22105–12. doi:10.1074/jbc.273.34.22105. PMID 9705355.
• Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
• Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.". Cell 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146.
• Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915.
• Parrill AL, Wang D, Bautista DL, et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820.
• Liu Y, Wada R, Yamashita T, et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.". J. Clin. Invest. 106 (8): 951–61. doi:10.1172/JCI10905. PMC 314347. PMID 11032855. //www.ncbi.nlm.nih.gov/pmc/articles/PMC314347/.
• Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.
• Hobson JP, Rosenfeldt HM, Barak LS, et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.". Science 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698.
• Lee MJ, Thangada S, Paik JH, et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.". Mol. Cell 8 (3): 693–704. doi:10.1016/S1097-2765(01)00324-0. PMID 11583630.

External links

• "Lysophospholipid Receptors: S₁P₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2993.
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.