GPR120
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| Omega-3 fatty acid receptor 1 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | O3FAR1; BMIQ10; GPR120; GPR129; GT01; PGR4 | |||||||
| External IDs | OMIM: 609044 MGI: 2147577 HomoloGene: 18769 IUPHAR: GPR120 ChEMBL: 5339 GeneCards: O3FAR1 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 338557 | 107221 | ||||||
| Ensembl | ENSG00000186188 | ENSMUSG00000054200 | ||||||
| UniProt | Q5NUL3 | Q7TMA4 | ||||||
| RefSeq (mRNA) | NM_001195755.1 | NM_181748.2 | ||||||
| RefSeq (protein) | NP_001182684.1 | NP_861413.1 | ||||||
| Location (UCSC) | Chr 10: 95.33 – 95.35 Mb |
Chr 19: 38.1 – 38.11 Mb |
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| PubMed search | [1] | [2] | ||||||
G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]
GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).[supplied by OMIM][2]
GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity[4]
[edit] References
- ^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
- ^ a b "Entrez Gene: GPR120 G protein-coupled receptor 120". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557.
- ^ Oh Da, Y.; Talukdar, S.; Bae, E.; Imamura, T.; Morinaga, H.; Fan, W.; Li, P.; Lu, W. et al. (2010). "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell 142 (5): 687–698. doi:10.1016/j.cell.2010.07.041. PMC 2956412. PMID 20813258. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2956412/.
- ^ Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
- Vassilatis DK, Hohmann JG, Zeng H et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517. //www.ncbi.nlm.nih.gov/pmc/articles/PMC153653/.
- Deloukas P, Earthrowl ME, Grafham DV et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Hirasawa A, Tsumaya K, Awaji T et al. (2005). "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120". Nat. Med. 11 (1): 90–4. doi:10.1038/nm1168. PMID 15619630.
- Oh JH, Yang JO, Hahn Y et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
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