FZD2

Frizzled family receptor 2
Identifiers
Symbols	FZD2; Fz2; fz-2; fzE2; hFz2
External IDs	OMIM: 600667 MGI: 1888513 HomoloGene: 20377 IUPHAR: FZD2 GeneCards: FZD2 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity • protein heterodimerization activity Cellular component • cytoplasm • plasma membrane • integral to membrane • neuron projection membrane • apical part of cell Biological process • cell activation • vasculature development • membranous septum morphogenesis • muscular septum morphogenesis • outflow tract morphogenesis • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • elevation of cytosolic calcium ion concentration • Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • axonogenesis • brain development • sensory perception of smell • gonad development • embryo development • neuron differentiation • positive regulation of cGMP metabolic process • epithelial cell differentiation • positive regulation of transcription, DNA-dependent • positive regulation of sequence-specific DNA binding transcription factor activity • hard palate development • canonical Wnt receptor signaling pathway • inner ear receptor cell development • cellular response to vitamin D • cellular response to growth factor stimulus • cellular response to peptide hormone stimulus • cochlea morphogenesis • planar cell polarity pathway involved in neural tube closure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2535	57265
Ensembl	ENSG00000180340	ENSMUSG00000050288
UniProt	Q14332	Q9JIP6
RefSeq (mRNA)	NM_001466.3	NM_020510.2
RefSeq (protein)	NP_001457.1	NP_065256.1
Location (UCSC)	Chr 17: 42.63 – 42.64 Mb	Chr 11: 102.6 – 102.61 Mb
PubMed search	[1]	[2]

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.

See also

• Frizzled

External links

• "Frizzled Receptors: FZD₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3060.

Further reading

• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21233/.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618. //www.ncbi.nlm.nih.gov/pmc/articles/PMC21479/.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.