FOXO4

Forkhead box O4
	; PDB rendering based on 1e17.
Available structures
PDB	1E17, 3L2C
Identifiers
Symbols	FOXO4; AFX; AFX1; MGC120490; MLLT7
External IDs	OMIM: 300033 MGI: 1891915 HomoloGene: 4342 GeneCards: FOXO4 Gene
Gene Ontology
Molecular function	• DNA binding; • double-stranded DNA binding; • sequence-specific DNA binding transcription factor activity; • sequence-specific enhancer binding RNA polymerase II transcription factor activity; • protein binding; • transcription factor binding; • DNA bending activity; • enzyme binding; • protein kinase binding; • sequence-specific DNA binding;
Cellular component	• nucleus; • nucleoplasm; • transcription factor complex; • cytoplasm; • cytosol;
Biological process	• G1 phase of mitotic cell cycle; • transcription, DNA-dependent; • regulation of transcription, DNA-dependent; • transcription from RNA polymerase II promoter; • cell cycle; • cell cycle arrest; • mitotic cell cycle G2/M transition DNA damage checkpoint; • pattern specification process; • muscle organ development; • negative regulation of cell proliferation; • insulin receptor signaling pathway; • embryo development; • tissue development; • negative regulation of angiogenesis; • cell differentiation; • positive regulation of transcription from RNA polymerase II promoter; • nerve growth factor receptor signaling pathway; • phosphatidylinositol-mediated signaling; • organ development; • regulation of sequence-specific DNA binding transcription factor activity; • negative regulation of smooth muscle cell differentiation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene.^[1]^[2]

[edit] See also

FOX proteins

[edit] Interactions

FOXO4 has been shown to interact with PIN1^[3] and Mdm2.^[4]

[edit] References

^ Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552.
^ "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4303.
^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, van der Groep Petra, van Diest Paul J, van der Horst Armando, Smits Alida M M, Burgering Boudewijn M T (Sep. 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. (United States) 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148.
^ Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, Jochemsen A G, Burgering Boudewijn M Th (2008). Cookson, Mark R.. ed. "Mdm2 Induces Mono-Ubiquitination of FOXO4". PLoS ONE (United States) 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMC 2475507. PMID 18665269. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2475507.

[edit] Further reading

Borkhardt A, Repp R, Haas OA, et al. (1997). "Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)". Oncogene 14 (2): 195–202. doi:10.1038/sj.onc.1200814. PMID 9010221.
Peters U, Haberhausen G, Kostrzewa M, et al. (1997). "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism". Hum. Genet. 100 (5–6): 569–72. doi:10.1007/s004390050553. PMID 9341872.
Kops GJ, de Ruiter ND, De Vries-Smits AM, et al. (1999). "Direct control of the Forkhead transcription factor AFX by protein kinase B". Nature 398 (6728): 630–4. doi:10.1038/19328. PMID 10217147.
Takaishi H, Konishi H, Matsuzaki H, et al. (1999). "Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11836–41. doi:10.1073/pnas.96.21.11836. PMC 18373. PMID 10518537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18373.
Medema RH, Kops GJ, Bos JL, Burgering BM (2000). "AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1". Nature 404 (6779): 782–7. doi:10.1038/35008115. PMID 10783894.
Furuyama T, Nakazawa T, Nakano I, Mori N (2001). "Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues". Biochem. J. 349 (Pt 2): 629–34. doi:10.1042/0264-6021:3490629. PMC 1221187. PMID 10880363. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221187.
Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2000). "1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX". J. Biomol. NMR 17 (2): 181–2. doi:10.1023/A:1008358816478. PMID 10921784.
Nasrin N, Ogg S, Cahill CM, et al. (2000). "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10412–7. doi:10.1073/pnas.190326997. PMC 27038. PMID 10973497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27038.
Brownawell AM, Kops GJ, Macara IG, Burgering BM (2001). "Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX". Mol. Cell. Biol. 21 (10): 3534–46. doi:10.1128/MCB.21.10.3534-3546.2001. PMC 100275. PMID 11313479. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100275.
Weigelt J, Climent I, Dahlman-Wright K, Wikström M (2001). "Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4)". Biochemistry 40 (20): 5861–9. doi:10.1021/bi001663w. PMID 11352721.
Schuur ER, Loktev AV, Sharma M, et al. (2001). "Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family". J. Biol. Chem. 276 (36): 33554–60. doi:10.1074/jbc.M105555200. PMID 11435445.
De Ruiter ND, Burgering BM, Bos JL (2001). "Regulation of the Forkhead Transcription Factor AFX by Ral-Dependent Phosphorylation of Threonines 447 and 451". Mol. Cell. Biol. 21 (23): 8225–35. doi:10.1128/MCB.21.23.8225-8235.2001. PMC 99987. PMID 11689711. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99987.
Tang TT, Dowbenko D, Jackson A, et al. (2002). "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor". J. Biol. Chem. 277 (16): 14255–65. doi:10.1074/jbc.M110901200. PMID 11777915.
Yang Z, Whelan J, Babb R, Bowen BR (2002). "An mRNA splice variant of the AFX gene with altered transcriptional activity". J. Biol. Chem. 277 (10): 8068–75. doi:10.1074/jbc.M106091200. PMID 11779849.
Kops GJ, Medema RH, Glassford J, et al. (2002). "Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors". Mol. Cell. Biol. 22 (7): 2025–36. doi:10.1128/MCB.22.7.2025-2036.2002. PMC 133681. PMID 11884591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133681.
So CW, Cleary ML (2002). "MLL-AFX Requires the Transcriptional Effector Domains of AFX To Transform Myeloid Progenitors and Transdominantly Interfere with Forkhead Protein Function". Mol. Cell. Biol. 22 (18): 6542–52. doi:10.1128/MCB.22.18.6542-6552.2002. PMC 135648. PMID 12192052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=135648.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism". J. Biol. Chem. 278 (32): 30125–35. doi:10.1074/jbc.M302042200. PMID 12761217.
Crossley LJ (2003). "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1". J. Leukoc. Biol. 74 (4): 583–92. doi:10.1189/jlb.0103020. PMID 12960271.

[edit] External links

MeSH MLLT7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[pmid7529552-0] Parry P, Wei Y, Evans G (Feb 1995). "Cloning and characterization of the t(X;11) breakpoint from a leukemic cell line identify a new member of the forkhead gene family". Genes Chromosomes Cancer 11 (2): 79–84. doi:10.1002/gcc.2870110203. PMID 7529552.

[entrez-1] "Entrez Gene: MLLT7 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4303.

[pmid18794148-2] Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, van der Groep Petra, van Diest Paul J, van der Horst Armando, Smits Alida M M, Burgering Boudewijn M T (Sep. 2008). "The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors". Cancer Res. (United States) 68 (18): 7597–605. doi:10.1158/0008-5472.CAN-08-1059. PMID 18794148.

[pmid18665269-3] Brenkman, Arjan B; de Keizer Peter L J, van den Broek Niels J F, Jochemsen A G, Burgering Boudewijn M Th (2008). Cookson, Mark R.. ed. "Mdm2 Induces Mono-Ubiquitination of FOXO4". PLoS ONE (United States) 3 (7): e2819. doi:10.1371/journal.pone.0002819. PMC 2475507. PMID 18665269. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2475507.

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Nov	DEC	Jan
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2010	2011	2012

FOXO4

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[edit] See also

[edit] Interactions

[edit] References

[edit] Further reading

[edit] External links

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