CEBPA

CAAT/enhancer binding protein (C/EBP), alpha
PDB rendering based on 1nqw.
Available structures PDB 1nwq
Identifiers
Symbols	CEBPA; C/EBP-alpha; CEBP
External IDs	OMIM: 116897 MGI: 99480 HomoloGene: 3211 GeneCards: CEBPA Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific enhancer binding RNA polymerase II transcription factor activity • protein binding • transcription factor binding • protein domain specific binding • protein complex binding • protein homodimerization activity • sequence-specific DNA binding • transcription regulatory region DNA binding • protein heterodimerization activity Cellular component • nucleus • nuclear matrix • Rb-E2F complex Biological process • urea cycle • negative regulation of transcription from RNA polymerase II promoter • liver development • embryonic placenta development • generation of precursor metabolites and energy • transcription, DNA-dependent • transcription, DNA-dependent • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • acute-phase response • mitochondrion organization • response to nutrient • cholesterol metabolic process • negative regulation of cell proliferation • cytokine-mediated signaling pathway • myeloid cell differentiation • macrophage differentiation • lung development • organ regeneration • response to vitamin B2 • interspecies interaction between organisms • positive regulation of fat cell differentiation • positive regulation of transcription from RNA polymerase III promoter • cell maturation • white fat cell differentiation • brown fat cell differentiation • response to glucocorticoid stimulus • cellular response to lithium ion • cellular response to organic cyclic compound Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1050	12606
Ensembl	ENSG00000245848	ENSMUSG00000034957
UniProt	P49715	Q3U2H8
RefSeq (mRNA)	NM_004364	NM_007678.3
RefSeq (protein)	NP_004355	NP_031704.2
Location (UCSC)	Chr 19: 33.79 – 33.79 Mb	Chr 7: 35.9 – 35.91 Mb
PubMed search	[1]	[2]

CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

See also

• caat-enhancer-binding proteins

Interactions

CEBPA has been shown to interact with Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4.

Further reading

• Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120. 
• Marcucci G, Mrózek K, Bloomfield CD (2005). "Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics.". Curr. Opin. Hematol. 12 (1): 68–75. doi:10.1097/01.moh.0000149608.29685.d1. PMID 15604894. 
• Leroy H, Roumier C, Huyghe P et al. (2005). "CEBPA point mutations in hematological malignancies". Leukemia 19 (3): 329–34. doi:10.1038/sj.leu.2403614. PMID 15674366. 

External links

• GeneReviews/NIH/NCBI/UW entry on Familial Acute Myeloid Leukemia (AML) with Mutated CEBPA
• MeSH CEBPA+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.