Altered patterns of effective connectivity in the brain’s default-mode network predicted both future dementia incidence and time to diagnosis.

The authors evaluated and integrated compositional and functional microbiota data using fecal samples taken from healthy individuals and multimodal neuroimaging.

The authors investigate first onsets of psychiatric disorders during perimenopause, finding higher incidence rates of major depressive disorder and mania.

De Giorgi and colleagues present a comprehensive analysis of pre-clinical and clinical studies examining the role of glucagon-like peptide-1 receptor agonists in mental disorders.

May marks Mental Health Month in much of the world. The 2025 theme selected by Mental Health America is Turn Awareness into Action. Over the course of the month, campaigns also highlight awareness of mental health for specific groups, including children and older adults, as well as communities and support networks. The theme links the notion of harnessing increased awareness of mental health, including recognition of individual journeys and advances in mental health science, with action through advocacy and policy. This year’s Mental Health Month comes against a backdrop of a steadily increasing prevalence of mental health disorders, rising youth mental health concerns, increased suicide rates, and political and social upheaval — reinforcing the need for the mental health research community to come together to stave off the backslide of progress and to collectively work for sustainable solutions during this crisis.

In this Perspective, the authors discuss the need to address the women’s brain health gap and its link to the concept of brain capital.

This systematic review analyzes how income and educational attainment are reported in psychedelic-assisted therapy trials. It reveals that only a minority of trials report this information and, when reported, the data have considerable variation in format and ambiguity in details. It also reveals disparities, with participants having higher income and being highly educated overrepresented in trials.

This study addresses variations in suicide rates across the United States and the impact of three county-level clusters of social determinants of health characteristics. The authors used unsupervised machine learning to analyze data from 2009 to 2019, revealing that remote areas, characterized by rurality and older populations, had the highest suicide rates, highlighting the need for addressing disparities with targeted interventions.

Physical neglect is a frequently overlooked form of child maltreatment in both research and practice. Here, we summarize the complexities of measuring physical neglect, and provide recommendations to guide future research and facilitate a deeper understanding of the effects of physical neglect on children’s development and wellbeing.

The authors used data from the UK Biobank to identify associations of self-rated symptoms of insomnia, depression and anxiety with cortical area, cortical thickness, subcortical volume, structural connectivity, functional connectivity, cognitive–emotional domains and neurochemical receptor distribution.