Coorgs from southwestern India are a culturally homogeneous but genetically heterogeneous group and earliest descendants of the Bronze Age migration into South Asia with enhanced ancestry proportions of the Middle East and population-specific drift.

The South American Cerrado has an estimated ~1605 tree species, yet > 2% make up half of all trees. Since 1995, the savanna lost 24 billion trees, threatening its biodiversity. Urgent conservation is needed to prevent irreversible loss.

Streamlined Phosphoproteomic Analysis of Rare CElls (SPARCE) enables robust quantification of proteomes and phosphoproteomes from just 1,000 FACS-sorted cells, advancing signalling analysis in rare populations.

Soil-mimicking microfluidic devices were developed to visualise and characterise the swimming behavior of soil bacteria B. diazoefficiens. Molity parameters, obtained with high statistical accuracy, enable simulations of their motion in real soils.

DNAJC5 facilitates LUAD progression through EGFR trafficking modulation, enhancing EGFR activity and downstream signaling while offering insights for innovative diagnostic and therapeutic strategies.

Targeted metabolite analysis reveals how inositol transport changes in symbiotic corals under heat stress, highlighting its critical role in shaping coral metabolite profiles and suggesting a key function in coral resilience to thermal stress.

SEC24D depletion induces osteogenic differentiation deficiency by inactivating the ATF6/TGF-β/Runx2 regulatory loop.

Las17/WASP is essential for actin polymerisation in yeast endocytosis. We show that SH3 domains of Sla1 compete with G-actin for binding in the Las17 polyproline region, revealing a mechanism for direct regulation of actin filament formation.

Human bone marrow MPS enables in vitro profiling of hematopoietic and immunotoxic effects of biologics, capturing lineage-specific responses and T cell–mediated cytotoxicity in a microfluidic system with optional autologous immune components.

Systematic transcriptomics analysis reveals the synergistic interaction of calorie restriction and rapamycin in extending cellular lifespan, identifying unique and overlapping gene regulation patterns in both yeast and human cells.

Audrey Dussutour is a Research Director at the National Center for Scientific Research (Toulouse, France), specializing in the adaptive behaviors of ants and slime molds. She has authored over 70 scientific papers and four award-winning science books. Dr. Dussutour has led two influential citizen science projects: “Raise Your Blob”, engaging 350,000 students, and “Behind the Blob”, mobilizing 15,000 volunteers to study climate change impact on slime molds. Her science communication efforts have been recognized with the National Order of Merit and the first CNRS Medal for scientific outreach. In this Q&A, she discusses the fascinating world of social insects and slime molds, the challenges of pursuing basic research outside mainstream funding priorities, and the importance of science education.

As progress is made in sex-inclusive preclinical research, the author highlights areas of research practice where significant development has been achieved & where more change is needed towards community accepted standards in equitable research

Commentary recommending research directions for cellular agriculture that may lead to more socially desirable directions for the industry.

In this Q&A, Christopher Smith, Postdoctoral Fellow at the American Museum of Natural History, discusses his journey from medical illustration to evolutionary anatomy, emphasizing how artistic skills have shaped his scientific research and how visual representation can drive scientific discovery.

Analysis shows that Latin American researchers and women published less on fossil mammals from Latin America than Global North researchers and male counterparts. Papers with more Latin American authors and those written in languages other than English received lower citation rates, highlighting their academic invisibility.

This paper identifies the top-50 priority questions for meiofaunal research, highlighting their critical roles in biogeochemical cycles and biodiversity. It calls for a balanced research agenda, international cooperation, and advances in technology to overcome current challenges and unlock meiofauna’s full potential.