OLIG1

Oligodendrocyte transcription factor 1
Identifiers
Symbols	OLIG1; BHLHB6; BHLHE21
External IDs	OMIM: 606385 MGI: 1355334 HomoloGene: 9667 GeneCards: OLIG1 Gene
Gene Ontology Molecular function • DNA binding • protein dimerization activity Cellular component • nucleus Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • neuron fate commitment Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116448	50914
Ensembl	ENSG00000184221	ENSMUSG00000046160
UniProt	Q8TAK6	Q9JKN5
RefSeq (mRNA)	NM_138983	NM_016968
RefSeq (protein)	NP_620450	NP_058664
Location (UCSC)	Chr 21: 34.44 – 34.44 Mb	Chr 16: 91.27 – 91.27 Mb
PubMed search	[1]	[2]

Oligodendrocyte transcription factor 1 is a protein that in humans is encoded by the OLIG1 gene.

Further reading

• Zhou Q, Wang S, Anderson DJ (2000). "Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors.". Neuron 25 (2): 331–43. doi:10.1016/S0896-6273(00)80898-3. PMID 10719889. 
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Takebayashi H, Yoshida S, Sugimori M, et al. (2001). "Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.". Mech. Dev. 99 (1-2): 143–8. doi:10.1016/S0925-4773(00)00466-4. PMID 11091082. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• McLellan AS, Langlands K, Kealey T (2003). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Gene Expr. Patterns 2 (3-4): 329–35. doi:10.1016/S0925-4773(02)00390-8. PMID 12617822. 
• McLellan AS, Langlands K, Kealey T (2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening.". Mech. Dev. 119 Suppl 1: S285–91. doi:10.1016/S0925-4773(03)00130-8. PMID 14516699. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Arnett HA, Fancy SP, Alberta JA, et al. (2005). "bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.". Science 306 (5704): 2111–5. doi:10.1126/science.1103709. PMID 15604411. 
• Jakovcevski I, Zecevic N (2006). "Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS.". J. Neurosci. 25 (44): 10064–73. doi:10.1523/JNEUROSCI.2324-05.2005. PMID 16267213. 
• Goris A, Yeo TW, Maranian M, et al. (2006). "Novel Olig 1-coding variants and susceptibility to multiple sclerosis.". J. Neurol. Neurosurg. Psychiatr. 77 (11): 1296–7. doi:10.1136/jnnp.2006.090639. PMC 2077377. PMID 16820418. 
• Ruf N, Martelli M, Weschke B, Uhlenberg B (2007). "Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 365–6. doi:10.1002/ajmg.b.30434. PMID 17171653. 
• Brena RM, Morrison C, Liyanarachchi S, et al. (2007). "Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.". PLoS Med. 4 (3): e108. doi:10.1371/journal.pmed.0040108. PMC 1831740. PMID 17388669. 

External links

• OLIG1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.