ZNF202
From Wikipedia, the free encyclopedia
| Zinc finger protein 202 | ||||||||
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| Identifiers | ||||||||
| Symbols | ZNF202; ZKSCAN10; ZSCAN42 | |||||||
| External IDs | OMIM: 603430 MGI: 1933401 HomoloGene: 68317 GeneCards: ZNF202 Gene | |||||||
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| RNA expression pattern | ||||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 7753 | 80902 | ||||||
| Ensembl | ENSG00000166261 | ENSMUSG00000025602 | ||||||
| UniProt | O95125 | E9Q2D3 | ||||||
| RefSeq (mRNA) | NM_003455 | NM_030713 | ||||||
| RefSeq (protein) | NP_003446 | NP_109638 | ||||||
| Location (UCSC) | Chr 11: 123.59 – 123.61 Mb |
Chr 9: 40.19 – 40.21 Mb |
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| PubMed search | [1] | [2] | ||||||
Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2] Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.
[edit] References
- ^ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM, Barbanti-Brodano G, Negrini M (Dec 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754.
- ^ "Entrez Gene: ZNF202 zinc finger protein 202". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7753.
- Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0.
[edit] Further reading
- Scanlan MJ, Gordan JD, Williamson B et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
- Schumacher C, Wang H, Honer C et al. (2000). "The SCAN domain mediates selective oligomerization". J. Biol. Chem. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
- Wagner S, Hess MA, Ormonde-Hanson P et al. (2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". J. Biol. Chem. 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193.
- Porsch-Ozcurumez M, Langmann T, Heimerl S et al. (2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". J. Biol. Chem. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031.
- Babb R, Bowen BR (2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". Biochem. J. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG et al. (2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551.
- Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". J. Lipid Res. 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280.
[edit] External links
- ZNF202 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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