SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]
[edit] References
- ^ Grech, D. M.; Spealman, R. D.; Bergman, J. (1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology 125 (2): 97–104. doi:10.1007/BF02249407. PMID 8783382. edit
- ^ Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics 283 (1): 29–38. PMID 9336305. edit
- ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics 293 (3): 1017–1026. PMID 10869406. edit
- ^ Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology 157 (2): 208–216. doi:10.1007/s002130100779. PMID 11594448. edit
- ^ Mutschler, N. H.; Bergman, J. (2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology 160 (4): 362–370. doi:10.1007/s00213-001-0976-z. PMID 11919663. edit
- ^ Desai, R. I.; Terry, P.; Katz, J. L. (2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior 81 (4): 843–848. doi:10.1016/j.pbb.2005.06.006. PMID 16000217. edit
- ^ Katz, J. L.; Kopajtic, T. A.; Terry, P. (2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology 17 (4): 303–309. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948. edit
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- Adamantanes: Amantadine
- Memantine
- Rimantadine; Aminotetralins: 7-OH-DPAT
- 8-OH-PBZI
- Rotigotine
- UH-232; Benzazepines: 6-Br-APB
- Fenoldopam
- SKF-38,393
- SKF-77,434
- SKF-81,297
- SKF-82,958
- SKF-83,959; Ergolines: Bromocriptine
- Cabergoline
- Dihydroergocryptine
- Epicriptine
- Lisuride
- LSD
- Pergolide; Dihydrexidine derivatives: 2-OH-NPA
- A-86,929
- Ciladopa
- Dihydrexidine
- Dinapsoline
- Dinoxyline
- Doxanthrine; Others: A-68,930
- A-77636
- A-412,997
- ABT-670
- ABT-724
- Aplindore
- Apomorphine
- Aripiprazole
- Bifeprunox
- BP-897
- CY-208,243
- Dizocilpine
- Etilevodopa
- Flibanserin
- Ketamine
- Melevodopa
- Modafinil
- Pardoprunox
- Phencyclidine
- PD-128,907
- PD-168,077
- PF-219,061
- Piribedil
- Pramipexole
- Propylnorapomorphine
- Pukateine
- Quinagolide
- Quinelorane
- Quinpirole
- RDS-127
- Ro10-5824
- Ropinirole
- Rotigotine
- Roxindole
- Salvinorin A
- SKF-89,145
- Sumanirole
- Terguride
- Umespirone
- WAY-100,635
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