HOXB5

Homeobox B5
PDB rendering based on 1hom.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1hom, 1san
Identifiers
Symbols	HOXB5; HHO.C10; HOX2; HOX2A; HU-1; Hox2.1
External IDs	OMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • transcription, DNA-dependent • anatomical structure morphogenesis • anterior/posterior pattern specification • endothelial cell differentiation • embryonic skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3215	15413
Ensembl	ENSG00000120075	ENSMUSG00000038700
UniProt	P09067	P09079
RefSeq (mRNA)	NM_002147	NM_008268
RefSeq (protein)	NP_002138	NP_032294
Location (UCSC)	Chr 17: 46.67 – 46.67 Mb	Chr 11: 96.3 – 96.31 Mb
PubMed search	[1]	[2]

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

See also

• Homeobox

Further reading

• Galang CK, Hauser CA (1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product.". New Biol. 4 (5): 558–68. PMID 1355360. 
• Peverali FA, D'Esposito M, Acampora D, et al. (1991). "Expression of HOX homeogenes in human neuroblastoma cell culture lines.". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366. 
• Giampaolo A, Acampora D, Zappavigna V, et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724. 
• Acampora D, D'Esposito M, Faiella A, et al. (1990). "The human HOX gene family.". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. 
• Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes.". Genome 31 (2): 745–56. PMID 2576652. 
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (1987). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432. 
• Hart CP, Awgulewitsch A, Fainsod A, et al. (1986). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.". Cell 43 (1): 9–18. doi:10.1016/0092-8674(85)90007-8. PMID 3000607. 
• Xu WM, Gorman PA, Rider SH, et al. (1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8563–7. doi:10.1073/pnas.85.22.8563. PMC 282499. PMID 3186746. 
• Simeone A, Mavilio F, Bottero L, et al. (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development.". Nature 320 (6064): 763–5. doi:10.1038/320763a0. PMID 3453105. 
• Hauser CA, Joyner AL, Klein RD, et al. (1986). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.". Cell 43 (1): 19–28. doi:10.1016/0092-8674(85)90008-X. PMID 4075393. 
• Levine M, Rubin GM, Tjian R (1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.". Cell 38 (3): 667–73. doi:10.1016/0092-8674(84)90261-7. PMID 6091895. 
• Galang CK, Hauser CA (1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro.". Mol. Cell. Biol. 13 (8): 4609–17. PMC 360087. PMID 8101633. 
• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877. 
• Kuliev A, Kukharenko V, Morozov G, et al. (1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies.". J. Assist. Reprod. Genet. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. 
• Sakach M, Safaei R (1997). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos.". Int. J. Dev. Neurosci. 14 (5): 567–73. doi:10.1016/0736-5748(96)00052-4. PMID 8930688. 
• Archavachotikul K, Ciccone TJ, Chinoy MR, et al. (2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation.". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L359–69. doi:10.1203/00006450-199904020-00286. PMID 11839528. 
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 

External links

• HOXB5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.