NPAS2
From Wikipedia, the free encyclopedia
Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.[1][2]
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[edit] Function
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.[3]
NPAS2 has been shown to be analogous to the function of CLOCK in CLOCK deficient mice.[4]
[edit] Interactions
NPAS2 has been shown to interact with:
[edit] References
- ^ Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (Mar 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc Natl Acad Sci USA 94 (2): 713–8. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
- ^ Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (May 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J Biol Chem 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
- ^ "Entrez Gene: NPAS2 neuronal PAS domain protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4862.
- ^ Debruyne JP (December 2008). "Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system". J. Genet. 87 (5): 437–46. PMC 2749070. PMID 19147932.
- ^ a b McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.
- ^ Hogenesch JB, Gu YZ, Jain S, Bradfield CA (May 1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5474–9. doi:10.1073/pnas.95.10.5474. PMC 20401. PMID 9576906.
- ^ Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P (February 2004). "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock". J. Biol. Chem. 279 (8): 7091–7. doi:10.1074/jbc.M311973200. PMID 14645221.
[edit] External links
- NPAS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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