CEBPD

CCAAT/enhancer binding protein (C/EBP), delta
Identifiers
Symbols	CEBPD; C/EBP-delta; CELF; CRP3; NF-IL6-beta
External IDs	OMIM: 116898 MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding Cellular component • nucleus Biological process • transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1052	12609
Ensembl	ENSG00000221869	n/a
UniProt	P49716	Q00322
RefSeq (mRNA)	NM_005195	NM_007679
RefSeq (protein)	NP_005186	NP_031705
Location (UCSC)	Chr 8: 48.65 – 48.65 Mb	n/a
PubMed search	[1]	[2]

CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.

Interactions

CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.

See also

• Ccaat-enhancer-binding proteins

Further reading

• Sladek FM, Darnell JE (1992). "Mechanisms of liver-specific gene expression.". Curr. Opin. Genet. Dev. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120. 
• Kinoshita S, Akira S, Kishimoto T (1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402. 
• Nagulapalli S, Pongubala JM, Atchison ML (1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).". J. Immunol. 155 (9): 4330–8. PMID 7594592. 
• Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p.". Cytogenet. Cell Genet. 70 (3–4): 188–91. doi:10.1159/000134030. PMID 7789168. 
• Cleutjens CB, van Eekelen CC, van Dekken H, et al. (1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590. 
• Chen PL, Riley DJ, Chen Y, Lee WH (1997). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes Dev. 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919. 
• Xia C, Cheshire JK, Patel H, Woo P (1998). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". Int. J. Biochem. Cell Biol. 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146. 
• Zhu Y, Saunders MA, Yeh H, et al. (2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". J. Biol. Chem. 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938. 
• Angeloni D, Lee JD, Johnson BE, et al. (2002). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Mol. Cell. Probes 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384. 
• Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Dearth LR, DeWille J (2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". J. Biol. Chem. 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732. 
• Milde-Langosch K, Löning T, Bamberger AM (2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Res. Treat. 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852. 
• Kovács KA, Steinmann M, Magistretti PJ, et al. (2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". J. Biol. Chem. 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754. 
• Chen YW, Hubal MJ, Hoffman EP, et al. (2004). "Molecular responses of human muscle to eccentric exercise". J. Appl. Physiol. 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. 
• Li R, Strohmeyer R, Liang Z, et al. (2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiol. Aging 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823. 
• Sivko GS, Sanford DC, Dearth LD, et al. (2005). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". J. Cell. Biochem. 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878. 

External links

• CEBPD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.