GPR56
From Wikipedia, the free encyclopedia
| G protein-coupled receptor 56 | ||||||||
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| Identifiers | ||||||||
| Symbols | GPR56; BFPP; TM7LN4; TM7XN1 | |||||||
| External IDs | OMIM: 604110 MGI: 1340051 HomoloGene: 4156 IUPHAR: GPR56 GeneCards: GPR56 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 9289 | 14766 | ||||||
| Ensembl | ENSG00000205336 | ENSMUSG00000031785 | ||||||
| UniProt | Q9Y653 | Q8K209 | ||||||
| RefSeq (mRNA) | NM_001145770.1 | NM_001198894.1 | ||||||
| RefSeq (protein) | NP_001139242.1 | NP_001185823.1 | ||||||
| Location (UCSC) | Chr 16: 57.64 – 57.7 Mb |
Chr 8: 94.98 – 95.01 Mb |
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| PubMed search | [1] | [2] | ||||||
G-protein coupled receptor 56 is a protein that in humans is encoded by the GPR56 gene. The gene product is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [1] [2] [3] [4][5][6] GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development [7],[8]. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of Natural killer cells[9]
In melanocytic cells GPR56 gene expression may be regulated by MITF.[10]
[edit] References
- ^ Yona, Stacey (2011). Adhesion-GPCRs. 1-200: Springer. ISBN 978-1-4419-7912-4.
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Araç, D; Boucard, AA; Bolliger, MF; Nguyen, J; Soltis, SM; Südhof, TC; Brunger, AT (2012 Feb 14). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.". The EMBO journal 31 (6): 1364-78. PMID 22333914.
- ^ Liu M, Parker RM, Darby K, Eyre HJ, Copeland NG, Crawford J, Gilbert DJ, Sutherland GR, Jenkins NA, Herzog H (May 1999). "GPR56, a novel secretin-like human G-protein-coupled receptor gene". Genomics 55 (3): 296–305. doi:10.1006/geno.1998.5644. PMID 10049584.
- ^ Zendman AJ, Cornelissen IM, Weidle UH, Ruiter DJ, van Muijen GN (Apr 1999). "TM7XN1, a novel human EGF-TM7-like cDNA, detected with mRNA differential display using human melanoma cell lines with different metastatic potential". FEBS Lett 446 (2-3): 292–8. doi:10.1016/S0014-5793(99)00230-6. PMID 10100861.
- ^ "Entrez Gene: GPR56 G protein-coupled receptor 56". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9289.
- ^ Xu, L (2010). "GPR56 interacts with extracellular matrix and regulates cancer progression.". Advances in experimental medicine and biology 706: 98-108. PMID 21618829.
- ^ Strokes, N; Piao, X (2010). "Adhesion-GPCRs in the CNS.". Advances in experimental medicine and biology 706: 87-97. PMID 21618828.
- ^ Peng, YM; van de Garde, MD; Cheng, KF; Baars, PA; Remmerswaal, EB; van Lier, RA; Mackay, CR; Lin, HH; Hamann, J (2011 Oct). "Specific expression of GPR56 by human cytotoxic lymphocytes.". Journal of leukocyte biology 90 (4): 735-40. PMID 21724806.
- ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
[edit] External links
[edit] Further reading
- Xu L, Hynes RO (2007). "GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.". Cell Cycle 6 (2): 160–5. doi:10.4161/cc.6.2.3760. PMID 17314516.
- Piao X, Basel-Vanagaite L, Straussberg R, et al. (2002). "An autosomal recessive form of bilateral frontoparietal polymicrogyria maps to chromosome 16q12.2-21.". Am. J. Hum. Genet. 70 (4): 1028–33. doi:10.1086/339552. PMC 379097. PMID 11845408. //www.ncbi.nlm.nih.gov/pmc/articles/PMC379097/.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.ncbi.nlm.nih.gov/pmc/articles/PMC403697/.
- Little KD, Hemler ME, Stipp CS (2005). "Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.". Mol. Biol. Cell 15 (5): 2375–87. doi:10.1091/mbc.E03-12-0886. PMC 404030. PMID 15004227. //www.ncbi.nlm.nih.gov/pmc/articles/PMC404030/.
- Piao X, Hill RS, Bodell A, et al. (2004). "G protein-coupled receptor-dependent development of human frontal cortex.". Science 303 (5666): 2033–6. doi:10.1126/science.1092780. PMID 15044805.
- Shashidhar S, Lorente G, Nagavarapu U, et al. (2005). "GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.". Oncogene 24 (10): 1673–82. doi:10.1038/sj.onc.1208395. PMID 15674329.
- Sud N, Sharma R, Ray R, et al. (2006). "Differential expression of G-protein coupled receptor 56 in human esophageal squamous cell carcinoma.". Cancer Lett. 233 (2): 265–70. doi:10.1016/j.canlet.2005.03.018. PMID 15916848.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Xu L, Begum S, Hearn JD, Hynes RO (2006). "GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9023–8. doi:10.1073/pnas.0602681103. PMC 1474142. PMID 16757564. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1474142/.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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