GPR128
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| G protein-coupled receptor 128 | ||||||||
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| Identifiers | ||||||||
| Symbols | GPR128; FLJ14454; FLJ16382; FLJ29035; MGC142011; MGC163260 | |||||||
| External IDs | OMIM: 612307 MGI: 2441732 HomoloGene: 13115 IUPHAR: GPR128 GeneCards: GPR128 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 84873 | 239853 | ||||||
| Ensembl | ENSG00000144820 | ENSMUSG00000022755 | ||||||
| UniProt | Q96K78 | Q8BM96 | ||||||
| RefSeq (mRNA) | NM_032787.2 | NM_172825.3 | ||||||
| RefSeq (protein) | NP_116176.2 | NP_766413.2 | ||||||
| Location (UCSC) | Chr 3: 100.33 – 100.41 Mb |
Chr 16: 56.72 – 56.8 Mb |
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| PubMed search | [1] | [2] | ||||||
Probable G-protein coupled receptor 128 is a protein that in humans is encoded by the GPR128 gene.[1][2] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[3][4]
[edit] References
- ^ "Entrez Gene: GPR128 G protein-coupled receptor 128". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84873.
- ^ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
- ^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
- ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914. //www.ncbi.nlm.nih.gov/pmc/articles/PMC3321182/.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
- Fredriksson R, Gloriam DE, Höglund PJ, et al. (2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.". Biochem. Biophys. Res. Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
- {{cite journal | author=Olsen JV, Blagoev B, Gnad F, et al. |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
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