PRX-03140

PRX-03140
Systematic (IUPAC) name
	4-hydroxy-7-isopropyl-6-oxo-N-[3-(1-piperidinyl)propyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carboxamide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	869493-21-0;
ATC code	None
PubChem	CID 54677674
ChemSpider	21377738
Chemical data
Formula	C19H27N3O3S
Mol. mass	377.501 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H27N3O3S/c1-13(2)22-18(25)15(16(23)14-7-12-26-19(14)22)17(24)20-8-6-11-21-9-4-3-5-10-21/h7,12-13,23H,3-6,8-11H2,1-2H3,(H,20,24); Key:SCHKZZSVELPJKU-UHFFFAOYSA-N ;

PRX-03140 is a partial agonist (18% relative to 5-HT^[1]) of the 5-HT₄ receptor that is being developed by EPIX Pharmaceuticals for Alzheimer's disease.^[2]

[edit] References

^ Shen F, Smith JA, Chang R, et al. (2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment". Neuropharmacology 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515. http://linkinghub.elsevier.com/retrieve/pii/S0028-3908(11)00106-7.
^ Shen, F (August 2011). "5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.". Neuropharmacology 61 (1-2): 69–79. doi:10.1016/j.neuropharm.2011.02.026. PMID 21392515.

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