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Sunifiram

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Sunifiram
Systematic (IUPAC) name
1-benzoyl-4-propanoylpiperazine
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 314728-85-3 YesY
ATC code  ?
PubChem CID 4223812
ChEMBL CHEMBL309176 N
Chemical data
Formula C14H18N2O2 
Mol. mass 246.304 g/mol
SMILES eMolecules & PubChem
 N (what is this?)  (verify)

Sunifiram (DM-235) is an ampakine drug which acts as a positive allosteric modulator of AMPA receptors,[1] and has nootropic effects in animal studies with significantly higher potency than piracetam.[2][3] A number of related compounds are known, the best known being unifiram (DM-232).[4][5][6]



[edit] References

  1. ^ Galeotti, N.; Ghelardini, C.; Pittaluga, A.; Pugliese, A.; Bartolini, A.; Manetti, D.; Romanelli, M.; Gualtieri, F. (2003). "AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)". Naunyn-Schmiedeberg's archives of pharmacology 368 (6): 538–545. DOI:10.1007/s00210-003-0812-6. PMID 14600801.  edit
  2. ^ Ghelardini, C.; Galeotti, N.; Gualtieri, F.; Romanelli, M.; Bucherelli, C.; Baldi, E.; Bartolini, A. (2002). "DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer". Naunyn-Schmiedeberg's archives of pharmacology 365 (6): 419–426. DOI:10.1007/s00210-002-0577-3. PMID 12070754.  edit
  3. ^ Romanelli, M.; Galeotti, N.; Ghelardini, C.; Manetti, D.; Martini, E.; Gualtieri, F. (2006). "Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers". CNS Drug Reviews 12 (1): 39–52. DOI:10.1111/j.1527-3458.2006.00039.x. PMID 16834757.  edit
  4. ^ Scapecchi, S.; Martini, E.; Manetti, D.; Ghelardini, C.; Martelli, C.; Dei, S.; Galeotti, N.; Guandalini, L. et al. (2004). "Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs". Bioorganic & Medicinal Chemistry 12 (1): 71–85. DOI:10.1016/j.bmc.2003.10.025. PMID 14697772.  edit
  5. ^ Martini, E.; Ghelardini, C.; Dei, S.; Guandalini, L.; Manetti, D.; Melchiorre, M.; Norcini, M.; Scapecchi, S. et al. (2008). "Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers". Bioorganic & Medicinal Chemistry 16 (3): 1431–1443. DOI:10.1016/j.bmc.2007.10.050. PMID 17981042.  edit
  6. ^ Martini, E.; Norcini, M.; Ghelardini, C.; Manetti, D.; Dei, S.; Guandalini, L.; Melchiorre, M.; Pagella, S. et al. (2008). "Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators". Bioorganic & Medicinal Chemistry 16 (23): 10034–10042. DOI:10.1016/j.bmc.2008.10.017. PMID 18954993.  edit


Psychostimulants, agents used for ADHD, and nootropics (N06B)
Centrally acting sympathomimetics
Xanthine derivatives
Glutamate receptor
Eugeroics / Benzhydryl compounds
Histamine H3 receptor antagonists
GABAA α5 inverse agonists
Dopamine D1 receptor agonists
α7 nicotinic agonists / PAMs
Prolyl endopeptidase inhibitors
Alpha-adrenergic agonists
Plants
Antioxidants
Other psychostimulants and nootropics

M: PSO/PSI

dsrd (o, p, m, p, a, d, s), sysi/epon, spvo

proc(eval/thrp), drug(N5A/5B/5C/6A/6B/6D)


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