Dibenzepin
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
| 10-(2-(dimethylamino)ethyl)-5-methyl-5H-dibenzo[b,e][1,4]diazepin-11(10H)-one | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | ? |
| Legal status | ℞ Prescription only |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | 25% (Oral) |
| Protein binding | 80% |
| Metabolism | Hepatic |
| Half-life | 5 hours |
| Excretion | Urine (80%), Feces (20%) |
| Identifiers | |
| CAS number | 4498-32-2 |
| ATC code | N06AA08 |
| PubChem | CID 9419 |
| ChemSpider | 9048  |
| UNII | 510SJZ1Y6L |
| KEGG | D07812 |
| Chemical data | |
| Formula | C18H21N3O |
| Mol. mass | 295.379 g/mol |
| SMILES | eMolecules & PubChem |
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Dibenzepin (Noveril, Anslopax, Deprex, Ecatril, Neodit, Victoril) is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression.[1][2][3] It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects.[4][5][6][7] Dibenzepin acts as a norepinephrine reuptake inhibitor, potent antihistamine, and weak anticholinergic.[4][5][8] It lacks any 5-HT2 antagonistic properties.[9]
[edit] See also
[edit] References
- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA323&dq=dibenzepin&as_brr=3&pg=PA323#v=onepage&q=&f=false.
- ^ Sittig, Marshall (1988). Pharmaceutical manufacturing encyclopedia. Park Ridge, N.J., U.S.A: Noyes Publications. ISBN 0-8155-1144-2. http://books.google.com/books?id=X2EyLsG4bcUC&lpg=PA470&dq=dibenzepin&as_brr=3&pg=PA470#v=onepage&q=&f=false.
- ^ Beresewicz M, Bidzińska E, Koszewska I, Puzyński S (1991). "[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]" (in Polish). Psychiatria Polska 25 (3-4): 13–8. PMID 1687987.
- ^ a b "Novartis (dibenzepin) - Prescribing Information". http://www.health.gov.il/units/pharmacy/trufot/alonim/2107.pdf.
- ^ a b Paloucek, Frank P.; Leikin, Jerrold B. (2007). Poisoning and Toxicology Handbook, Fourth Edition (Poisoning and Toxicology Handbook (Leiken & Paloucek's)). Informa Healthcare. ISBN 1-4200-4479-6. http://books.google.com/books?id=0Bw2UJTC_uMC&lpg=PA242&dq=dibenzepin&lr=lang_en&as_drrb_is=q&as_minm_is=0&as_miny_is=&as_maxm_is=0&as_maxy_is=&as_brr=3&pg=PA242#v=onepage&q=&f=false.
- ^ Gowardman M, Brown RA (March 1976). "Dibenzepin and amitriptyline in depressive states: comparative double-blind trial". The New Zealand Medical Journal 83 (560): 194–7. PMID 6928.
- ^ Baron DP, Unger HR, Williams HE, Knight RG (April 1976). "A double blind study of the antidepressants dibenzepin (Noveril) and amitriptyline". The New Zealand Medical Journal 83 (562): 273–4. PMID 8749.
- ^ Rehavi M, Maayani S, Goldstein L, Assael M, Sokolovsky M (August 1977). "Antimuscarinic properties of antidepressants: dibenzepin (Noveril)". Psychopharmacology 54 (1): 35–8. doi:10.1007/BF00426538. PMID 20647.
- ^ Closse A, Jaton AL (July 1984). "Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 326 (4): 291–3. PMID 6148707.
[edit] External links
- "Novartis - Noveral (dibenzepin) - Prescribing Information". http://www.health.gov.il/units/pharmacy/trufot/alonim/2107.pdf.
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