Fezolamine

Fezolamine
Systematic (IUPAC) name
	3-(3,4-diphenyl- 1H-pyrazol- 1-yl)- N,N-dimethylpropan- 1-amine
Clinical data
Pregnancy cat.	?
Legal status	Uncontrolled
Routes	Oral
Identifiers
CAS number	80410-36-2
ATC code	None
PubChem	CID 54567
ChemSpider	49284
UNII	1133E05F6C
Chemical data
Formula	C20H23N3
Mol. mass	305.42 g/mol
SMILES	eMolecules & PubChem

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Fezolamine (Win-41,528-2) is a drug which was investigated by Sterling^[1] as an antidepressant in the 1980s.^[2]^[3] It acts as a serotonin, norepinephrine, and dopamine reuptake inhibitor, with 3- to 4-fold preference for the former neurotransmitter.^[2] It was found to be effective and well-tolerated in clinical trials but was never marketed.^[3]

[edit] See also

^ US Patent 4182895 - 1-Amino-lower-alkyl-3,4-diphenyl-1H-pyrazoles
^ ^a ^b Baizman ER, Ezrin AM, Ferrari RA, Luttinger D (October 1987). "Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models". The Journal of Pharmacology and Experimental Therapeutics 243 (1): 40–54. PMID 3668867. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3668867.
^ ^a ^b Zisook S, Mendels J, Janowsky D, Feighner J, Lee JC, Fritz A (1987). "Efficacy and safety of fezolamine in depressed patients". Neuropsychobiology 17 (3): 133–8. doi:10.1159/000118353. PMID 3683802.