SKF-83,959

SKF-83,959
Systematic (IUPAC) name
	6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
ATC code	?
PubChem	CID 24278699
ChemSpider	10131933
ChEMBL	CHEMBL520992
Chemical data
Formula	C18H20ClNO2
Mol. mass	317.810 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H ; Key:FHYWNBUFNGHNCP-UHFFFAOYSA-N ;
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SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as a selective D₁ receptor antagonist and D₅ receptor full agonist, as evidenced by the fact that it has high affinity for both receptors and stimulates the D₅-linked PLC/PI second messenger pathway without affecting the cAMP/AC pathway which is linked to D₁.^[1]^[2]^[3]^[4]

[edit] References

^ Jin LQ, Goswami S, Cai G, Zhen X, Friedman E (April 2003). "SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain". Journal of Neurochemistry 85 (2): 378–86. PMID 12675914.
^ Zhen X, Goswami S, Friedman E (April 2005). "The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959". Pharmacology, Biochemistry, and Behavior 80 (4): 597–601. doi:10.1016/j.pbb.2005.01.016. PMID 15820529.
^ Zhang ZJ, Jiang XL, Zhang SE, Hough CJ, Li H, Chen JG, Zhen XC (2005). "The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm". Neuroscience Letters 382 (1-2): 134–8. doi:10.1016/j.neulet.2005.03.001. PMID 15911136.
^ Sahu A, Tyeryar KR, Vongtau HO, Sibley DR, Undieh AS (March 2009). "D5 dopamine receptors are required for dopaminergic activation of phospholipase C". Molecular Pharmacology 75 (3): 447–53. doi:10.1124/mol.108.053017. PMID 19047479. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=19047479.

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