Teniloxazine

Teniloxazine
Systematic (IUPAC) name
	2-{[2-(thiophen-2-ylmethyl)phenoxy]methyl}morpholine
Clinical data
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	62473-79-4 ; 62473-80-7 (maleate)
ATC code	None
PubChem	CID 119114
ChemSpider	106426
UNII	95Q6WNP25P
Synonyms	Y-8894
Chemical data
Formula	C16H19NO2S
Mol. mass	289.393 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C16H19NO2S/c1-2-6-16(19-12-14-11-17-7-8-18-14)13(4-1)10-15-5-3-9-20-15/h1-6,9,14,17H,7-8,10-12H2 ; Key:OILWWIVKIDXCIB-UHFFFAOYSA-N ;
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Teniloxazine (Lucelan, Metatone), also known as sufoxazine/sulfoxazine, is a drug which is marketed in Japan.^[1] Though initially investigated as a neuroprotective and nootropic agent for the treatment of cerebrovascular insufficiency in the 1980s,^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9] it was ultimately developed and approved as an antidepressant instead.^[10] It acts as a potent norepinephrine reuptake inhibitor, with fair selectivity over the serotonin and dopamine transporters, and also behaves as an antagonist at the 5-HT_2A receptor.^[7]^[10]^[11]

[edit] See also

[edit] References

^ C. R Ganellin; D. J Triggle; F.. Macdonald (1997). Dictionary of pharmacological agents. CRC Press. pp. 1905. ISBN 978-0-412-46630-4. http://books.google.com/books?id=A0THacd46ZsC&pg=PA1905. Retrieved 27 October 2011.
^ Anami K, Yamamoto Y, Setoguchi M (February 1985). "[Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 85 (2): 71–7. PMID 2859238.
^ Izumi N, Yasuda H (October 1985). "[Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 86 (4): 323–8. PMID 4085932.
^ Usa T, Morimoto Y, Fukuda T, Anami K, Setoguchi M, Maruyama Y (October 1986). "[Pharmacological studies on Y-8894. (III). Its effect on the abnormal electrocorticogram induced by destruction of the internal capsule]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (4): 289–97. PMID 3491778.
^ Yasuda H, Izumi N, Nakanishi M, Anami K, Maruyama Y (November 1986). "[Pharmacological studies on Y-8894. (IV). Ameliorative effect on a cerebral energy metabolism disorder induced by KCN]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (5): 363–7. PMID 3817653.
^ Anami K, Yamamoto Y, Setoguchi M, Maruyama Y (March 1987). "[Pharmacological studies on Y-8894. (V) Effect on learning and memory in intact and experimentally amnesic rats]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 89 (3): 145–53. PMID 2884174.
^ ^a ^b Setoguchi M, Takehara S, Sakamori M, Anami K, Maruyama Y (July 1987). "[Pharmacological studies on Y-8894 (VI). The effect on monoamine uptake and turnover in mouse brain]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 90 (1): 41–9. PMID 2443434.
^ Yasumatsu H, Yamamoto Y, Takamuku H, et al. (December 1987). "[Pharmacological studies on Y-8894. (VII). Effects on transient cerebral ischemia-induced amnesia in rats]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 90 (6): 321–30. PMID 3443414.
^ Anami K, Setoguchi M, Senoh H (August 1988). "[Pharmacological studies on Y-8894. (VIII). Effects on learning and memory in the radial maze task in mice]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 92 (2): 113–8. PMID 3224898.
^ ^a ^b Ogura C, Kishimoto A, Kunimoto N, et al. (May 1987). "Clinical pharmacology of a new antidepressant, Y-8894 in healthy young and elderly volunteers". British Journal of Clinical Pharmacology 23 (5): 537–43. PMC 1386189. PMID 3593624. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1386189.
^ "Therapeutic Agent for Attention-Deficit Hyperactivity Disorder - Google Patents" (HTML). http://www.google.com/patents?id=UNCzAAAAEBAJ&printsec=abstract#v=onepage. Retrieved October 27, 2011.

[GanellinTriggle1997-0] C. R Ganellin; D. J Triggle; F.. Macdonald (1997). Dictionary of pharmacological agents. CRC Press. pp. 1905. ISBN 978-0-412-46630-4. http://books.google.com/books?id=A0THacd46ZsC&pg=PA1905. Retrieved 27 October 2011.

[pmid2859238-1] Anami K, Yamamoto Y, Setoguchi M (February 1985). "[Pharmacological studies on sufoxazine (Y-8894). (I) Effects on experimental amnesia in mice]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 85 (2): 71–7. PMID 2859238.

[pmid4085932-2] Izumi N, Yasuda H (October 1985). "[Pharmacological studies on sufoxazine (Y-8894). (II). Anti-anoxic effect]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 86 (4): 323–8. PMID 4085932.

[pmid3491778-3] Usa T, Morimoto Y, Fukuda T, Anami K, Setoguchi M, Maruyama Y (October 1986). "[Pharmacological studies on Y-8894. (III). Its effect on the abnormal electrocorticogram induced by destruction of the internal capsule]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (4): 289–97. PMID 3491778.

[pmid3817653-4] Yasuda H, Izumi N, Nakanishi M, Anami K, Maruyama Y (November 1986). "[Pharmacological studies on Y-8894. (IV). Ameliorative effect on a cerebral energy metabolism disorder induced by KCN]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 88 (5): 363–7. PMID 3817653.

[pmid2884174-5] Anami K, Yamamoto Y, Setoguchi M, Maruyama Y (March 1987). "[Pharmacological studies on Y-8894. (V) Effect on learning and memory in intact and experimentally amnesic rats]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 89 (3): 145–53. PMID 2884174.

[pmid2443434-6] Setoguchi M, Takehara S, Sakamori M, Anami K, Maruyama Y (July 1987). "[Pharmacological studies on Y-8894 (VI). The effect on monoamine uptake and turnover in mouse brain]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 90 (1): 41–9. PMID 2443434.

[pmid3443414-7] Yasumatsu H, Yamamoto Y, Takamuku H, et al. (December 1987). "[Pharmacological studies on Y-8894. (VII). Effects on transient cerebral ischemia-induced amnesia in rats]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 90 (6): 321–30. PMID 3443414.

[pmid3224898-8] Anami K, Setoguchi M, Senoh H (August 1988). "[Pharmacological studies on Y-8894. (VIII). Effects on learning and memory in the radial maze task in mice]" (in Japanese). Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 92 (2): 113–8. PMID 3224898.

[pmid3593624-9] Ogura C, Kishimoto A, Kunimoto N, et al. (May 1987). "Clinical pharmacology of a new antidepressant, Y-8894 in healthy young and elderly volunteers". British Journal of Clinical Pharmacology 23 (5): 537–43. PMC 1386189. PMID 3593624. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1386189.

[Kuriyama2009-10] "Therapeutic Agent for Attention-Deficit Hyperactivity Disorder - Google Patents" (HTML). http://www.google.com/patents?id=UNCzAAAAEBAJ&printsec=abstract#v=onepage. Retrieved October 27, 2011.

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Teniloxazine

[edit] See also

[edit] References

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