HES1

Hairy and enhancer of split 1, (Drosophila)
Identifiers
Symbols	HES1; FLJ20408; HES-1; HHL; HRY; bHLHb39
External IDs	OMIM: 139605 MGI: 104853 HomoloGene: 38067 GeneCards: HES1 Gene
Gene Ontology
Molecular function	• DNA binding; • sequence-specific DNA binding transcription factor activity; • histone deacetylase binding; • HLH domain binding; • N-box binding;
Cellular component	• intracellular; • nucleus; • cytoplasm; • protein complex;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • in utero embryonic development; • liver development; • transcription, DNA-dependent; • cell adhesion; • Notch signaling pathway; • smoothened signaling pathway; • nervous system development; • positive regulation of cell proliferation; • midbrain-hindbrain boundary morphogenesis; • oculomotor nerve development; • trochlear nerve development; • hindbrain morphogenesis; • neural tube development; • pituitary gland development; • lung development; • midbrain development; • endocrine pancreas development; • auditory receptor cell fate determination; • cell fate commitment; • negative regulation of auditory receptor cell differentiation; • negative regulation of neuron differentiation; • negative regulation of transcription, DNA-dependent; • positive regulation of transcription from RNA polymerase II promoter; • cell maturation; • cell morphogenesis involved in neuron differentiation; • regulation of neurogenesis; • regulation of timing of neuron differentiation; • negative regulation of stomach neuroendocrine cell differentiation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Transcription factor HES-1 is a protein that in humans is encoded by the HES1 gene.^[1]^[2]

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.^[2]

[edit] Interactions

HES1 has been shown to interact with TLE2^[3] and Sirtuin 1.^[4]

[edit] References

^ Feder JN, Li L, Jan LY, Jan YN (Jul 1994). "Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy". Genomics 20 (1): 56–61. doi:10.1006/geno.1994.1126. PMID 8020957.
^ ^a ^b "Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3280.
^ Grbavec, D; Lo R, Liu Y, Stifani S (Dec. 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. (GERMANY) 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.
^ Takata, Takehiko; Ishikawa Fuyuki (Jan. 2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. (United States) 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. ISSN 0006-291X. PMID 12535671.

[edit] Further reading

Takebayashi K, Sasai Y, Sakai Y, (1994). "Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements". J. Biol. Chem. 269 (7): 5150–6. PMID 7906273.
Grbavec D, Stifani S (1996). "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif". Biochem. Biophys. Res. Commun. 223 (3): 701–5. doi:10.1006/bbrc.1996.0959. PMID 8687460.
Ström A, Castella P, Rockwood J, (1998). "Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix-loop-helix repressor of neuronal differentiation". Genes Dev. 11 (23): 3168–81. doi:10.1101/gad.11.23.3168. PMC 316755. PMID 9389649. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316755.
Votruba M, Payne A, Moore AT, Bhattacharya SS (1998). "Dominant optic atrophy: exclusion and fine genetic mapping of the candidate gene, HRY". Mamm. Genome 9 (10): 784–7. doi:10.1007/s003359900867. PMID 9745030.
Bae S, Bessho Y, Hojo M, Kageyama R (2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development 127 (13): 2933–43. PMID 10851137.
Yao J, Lai E, Stifani S (2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Mol. Cell. Biol. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86788.
Iso T, Sartorelli V, Poizat C, (2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. doi:10.1128/MCB.21.17.6080-6089.2001. PMC 87325. PMID 11486045. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87325.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
Jögi A, Persson P, Grynfeld A, (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. Chem. 277 (11): 9118–26. doi:10.1074/jbc.M107713200. PMID 11756408.
Kunisato A, Chiba S, Nakagami-Yamaguchi E, (2003). "HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo". Blood 101 (5): 1777–83. doi:10.1182/blood-2002-07-2051. PMID 12406868.
Strausberg RL, Feingold EA, Grouse LH, (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Takata T, Ishikawa F (2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. PMID 12535671.
Gratton MO, Torban E, Jasmin SB, (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=193938.
Ota T, Suzuki Y, Nishikawa T, (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Thomsen JS, Kietz S, Ström A, Gustafsson JA (2004). "HES-1, a novel target gene for the aryl hydrocarbon receptor". Mol. Pharmacol. 65 (1): 165–71. doi:10.1124/mol.65.1.165. PMID 14722248.
Kamakura S, Oishi K, Yoshimatsu T, (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153.
Persson P, Stockhausen MT, Påhlman S, Axelson H (2005). "Ubiquilin-1 is a novel HASH-1-complexing protein that regulates levels of neuronal bHLH transcription factors in human neuroblastoma cells". Int. J. Oncol. 25 (5): 1213–21. PMID 15492808.
Aguilera C, Hoya-Arias R, Haegeman G, (2004). "Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16537–42. doi:10.1073/pnas.0404429101. PMC 534509. PMID 15536134. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=534509.
Fryer CJ, White JB, Jones KA (2005). "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover". Mol. Cell 16 (4): 509–20. doi:10.1016/j.molcel.2004.10.014. PMID 15546612.

[edit] External links

MeSH HES1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid8020957-0] Feder JN, Li L, Jan LY, Jan YN (Jul 1994). "Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy". Genomics 20 (1): 56–61. doi:10.1006/geno.1994.1126. PMID 8020957.

[entrez-1] "Entrez Gene: HES1 hairy and enhancer of split 1, (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3280.

[pmid9874198-2] Grbavec, D; Lo R, Liu Y, Stifani S (Dec. 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". Eur. J. Biochem. (GERMANY) 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. ISSN 0014-2956. PMID 9874198.

[pmid12535671-3] Takata, Takehiko; Ishikawa Fuyuki (Jan. 2003). "Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression". Biochem. Biophys. Res. Commun. (United States) 301 (1): 250–7. doi:10.1016/S0006-291X(02)03020-6. ISSN 0006-291X. PMID 12535671.

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HES1

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