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From Wikipedia, the free encyclopedia
| Myelin transcription factor 1 | ||||||||
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| Identifiers | ||||||||
| Symbols | MYT1; C20orf36; MTF1; MYTI; PLPB1 | |||||||
| External IDs | OMIM: 600379 MGI: 1100535 HomoloGene: 3332 GeneCards: MYT1 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 4661 | 17932 | ||||||
| Ensembl | ENSG00000196132 | ENSMUSG00000010505 | ||||||
| UniProt | Q01538 | Q3UXY0 | ||||||
| RefSeq (mRNA) | NM_004535 | NM_008665 | ||||||
| RefSeq (protein) | NP_004526 | NP_032691 | ||||||
| Location (UCSC) | Chr 20: 62.78 – 62.87 Mb |
Chr 2: 181.5 – 181.56 Mb |
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| PubMed search | [1] | [2] |
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[3]
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[edit] Interactions
MYT1 has been shown to interact with PIN1.[4]
[edit] References
- ^ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Mol Cell Biol 12 (12): 5632–9. PMC 360502. PMID 1280325. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360502.
- ^ Booher RN, Holman PS, Fattaey A (Oct 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J Biol Chem 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
- ^ a b "Entrez Gene: MYT1 myelin transcription factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4661.
- ^ Wells, N J; Watanabe N, Tokusumi T, Jiang W, Verdecia M A, Hunter T (Oct. 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". J. Cell. Sci. (ENGLAND) 112 ( Pt 19): 3361–71. ISSN 0021-9533. PMID 10504341.
[edit] Further reading
- Gogate N, Verma L, Zhou JM et al. (1994). "Plasticity in the adult human oligodendrocyte lineage". J. Neurosci. 14 (8): 4571–87. PMID 7519254.
- Armstrong RC, Kim JG, Hudson LD (1996). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.
- Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol. Cell. Biol. 17 (2): 571–83. PMC 231782. PMID 9001210. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231782.
- Kim JG, Armstrong RC, v Agoston D et al. (1998). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". J. Neurosci. Res. 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037.
- Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hirayama A, Oka A, Ito M et al. (2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Res. Dev. Brain Res. 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
- Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Mol. Cell. Neurosci. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
- Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (2007). "Myelin Transcription Factor 1 (Myt1) Expression in Demyelinated Lesions of Rodent and Human CNS". Glia 55 (7): 687–97. doi:10.1002/glia.20492. PMC 2789289. PMID 17330875. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2789289.
[edit] External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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