STAT2

Signal transducer and activator of transcription 2, 113kDa
Identifiers
Symbols	STAT2; ISGF-3; MGC59816; P113; STAT113
External IDs	OMIM: 600556 MGI: 103039 HomoloGene: 3952 GeneCards: STAT2 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • signal transducer activity • calcium ion binding • protein binding Cellular component • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol • cytosol • plasma membrane Biological process • regulation of transcription from RNA polymerase II promoter • JAK-STAT cascade • response to virus • cytokine-mediated signaling pathway • interspecies interaction between organisms • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6773	20847
Ensembl	ENSG00000170581	ENSMUSG00000040033
UniProt	P52630	n/a
RefSeq (mRNA)	NM_005419.3	NM_019963.1
RefSeq (protein)	NP_005410.1	NP_064347.1
Location (UCSC)	Chr 12: 56.74 – 56.75 Mb	Chr 10: 127.71 – 127.73 Mb
PubMed search	[1]	[2]

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene.

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

Interactions

STAT2 has been shown to interact with MED14, CREB-binding protein, SMARCA4, STAT1, IFNAR2, IFNAR1 and ISGF3G.

Further reading

• Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction.". Intervirology 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714. 
• Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028. 
• Fu XY, Schindler C, Improta T, et al. (1992). "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7840–3. doi:10.1073/pnas.89.16.7840. PMC 49807. PMID 1502204. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=49807. 
• Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568. 
• Marrero MB, Schieffer B, Paxton WG, et al. (1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor". Nature 375 (6528): 247–50. doi:10.1038/375247a0. PMID 7746328. 
• Sugiyama T, Nishio Y, Kishimoto T, Akira S (1996). "Identification of alternative splicing form of Stat2". FEBS Lett. 381 (3): 191–4. doi:10.1016/0014-5793(96)00121-4. PMID 8601453. 
• Yan H, Krishnan K, Greenlund AC, et al. (1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. 15 (5): 1064–74. PMC 450004. PMID 8605876. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450004. 
• Gupta S, Yan H, Wong LH, et al. (1996). "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals". EMBO J. 15 (5): 1075–84. PMC 450005. PMID 8605877. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=450005. 
• Li X, Leung S, Qureshi S, et al. (1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha". J. Biol. Chem. 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. PMID 8621447. 
• Bhattacharya S, Eckner R, Grossman S, et al. (1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha". Nature 383 (6598): 344–7. doi:10.1038/383344a0. PMID 8848048. 
• Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12): 6957–64. PMC 231699. PMID 8943351. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231699. 
• Bluyssen HA, Levy DE (1997). "Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA". J. Biol. Chem. 272 (7): 4600–5. doi:10.1074/jbc.272.7.4600. PMID 9020188. 
• Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. PMC 232052. PMID 9121453. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232052. 
• Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679. 
• Mowen K, David M (1998). "Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1". J. Biol. Chem. 273 (46): 30073–6. doi:10.1074/jbc.273.46.30073. PMID 9804758. 
• Dumler I, Kopmann A, Wagner K, et al. (1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". J. Biol. Chem. 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. PMID 10446176. 
• Paulson M, Pisharody S, Pan L, et al. (1999). "Stat protein transactivation domains recruit p300/CBP through widely divergent sequences". J. Biol. Chem. 274 (36): 25343–9. doi:10.1074/jbc.274.36.25343. PMID 10464260. 
• Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells". J. Immunol. 163 (7): 3834–41. PMID 10490982. 
• Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, et al. (1999). "The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway". FASEB J. 13 (13): 1699–710. PMID 10506573. 

External links

• MeSH STAT2+Transcription+Factor
• FactorBook STAT2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.