GATA3

GATA binding protein 3
Identifiers
Symbols	GATA3; HDR; MGC2346; MGC5199; MGC5445
External IDs	OMIM: 131320 MGI: 95663 HomoloGene: 1550 GeneCards: GATA3 Gene
Gene Ontology Molecular function • transcription regulatory region sequence-specific DNA binding • core promoter proximal region sequence-specific DNA binding • core promoter sequence-specific DNA binding • nucleic acid binding transcription factor activity • nucleic acid binding transcription factor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • protein binding • transcription factor binding • zinc ion binding • transcription regulatory region DNA binding • metal ion binding • E-box binding • HMG box domain binding Cellular component • nuclear chromatin • nucleus • nucleoplasm • nucleolus • nucleolus Biological process • negative regulation of transcription from RNA polymerase II promoter • cell fate determination • kidney development • mesonephros development • aortic valve morphogenesis • cardiac right ventricle morphogenesis • ventricular septum development • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • defense response • signal transduction • blood coagulation • negative regulation of cell proliferation • male gonad development • response to virus • anatomical structure morphogenesis • positive regulation of signal transduction • positive regulation of endothelial cell migration • phosphatidylinositol 3-kinase cascade • TOR signaling cascade • positive regulation of interleukin-4 production • negative regulation of mammary gland epithelial cell proliferation • cellular response to interferon-alpha • glial cell-derived neurotrophic factor receptor signaling pathway • regulation of cytokine biosynthetic process • norepinephrine biosynthetic process • ear development • response to estrogen stimulus • positive regulation of T cell differentiation • negative regulation of fat cell differentiation • negative regulation of cell cycle • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • sympathetic nervous system development • anatomical structure formation involved in morphogenesis • negative regulation of inflammatory response • T cell receptor signaling pathway • positive regulation of protein kinase B signaling cascade • pharyngeal system development • uterus development • mesenchymal to epithelial transition • ureteric bud formation • canonical Wnt receptor signaling pathway involved in metanephric kidney development • cellular response to interleukin-4 • cellular response to tumor necrosis factor • positive regulation of ureteric bud formation • nephric duct morphogenesis • nephric duct formation • regulation of nephron tubule epithelial cell differentiation • lymphocyte migration • negative regulation of cell motility • negative regulation of endothelial cell apoptosis • negative regulation of cell proliferation involved in mesonephros development • positive regulation of thyroid hormone generation • positive regulation of interleukin-5 secretion • positive regulation of interleukin-13 secretion • positive regulation of interleukin-13 secretion • positive regulation of transcription regulatory region DNA binding • regulation of cellular response to X-ray • fibroblast growth factor receptor signaling pathway involved in ureteric bud formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2625	14462
Ensembl	ENSG00000107485	ENSMUSG00000015619
UniProt	P23771	Q3TZD6
RefSeq (mRNA)	NM_001002295.1	NM_008091.3
RefSeq (protein)	NP_001002295.1	NP_032117.1
Location (UCSC)	Chr 10: 8.1 – 8.12 Mb	Chr 2: 9.78 – 9.81 Mb
PubMed search	[1]	[2]

Trans-acting T-cell-specific transcription factor GATA-3 is a protein that in humans is encoded by the GATA3 gene.

GATA-3 belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells. GATA-3 was shown to be required for the luminal A type of breast cancer, intertwined in pathways with ERα . However, it is also hypothesised that GATA-3 may play tissue specific roles .

Clinical significance

Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.

Interactions

GATA3 has been shown to interact with LMO1.

See also

• GATA transcription factor

Further reading

• Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate". Breast Cancer Res. 9 (2): 302. doi:10.1186/bcr1661. PMC 1868924. PMID 17381824. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1868924. 
• Ho IC, Vorhees P, Marin N, et al. (1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene". EMBO J. 10 (5): 1187–92. PMC 452772. PMID 1827068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452772. 
• Marine J, Winoto A (1991). "The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7284–8. doi:10.1073/pnas.88.16.7284. PMC 52279. PMID 1871134. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52279. 
• Ko LJ, Yamamoto M, Leonard MW, et al. (1991). "Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer". Mol. Cell. Biol. 11 (5): 2778–84. PMC 360054. PMID 2017177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360054. 
• Siegel MD, Zhang DH, Ray P, Ray A (1995). "Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements". J. Biol. Chem. 270 (41): 24548–55. doi:10.1074/jbc.270.41.24548. PMID 7592673. 
• Labastie MC, Bories D, Chabret C, et al. (1994). "Structure and expression of the human GATA3 gene". Genomics 21 (1): 1–6. doi:10.1006/geno.1994.1217. PMID 8088776. 
• Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL". J. Biol. Chem. 272 (7): 4576–81. doi:10.1074/jbc.272.7.4576. PMID 9020185. 
• Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. 18 (12): 6939–50. PMC 109277. PMID 9819382. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109277. 
• Yang GP, Ross DT, Kuang WW, et al. (1999). "Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes". Nucleic Acids Res. 27 (6): 1517–23. doi:10.1093/nar/27.6.1517. PMC 148347. PMID 10037815. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=148347. 
• Blumenthal SG, Aichele G, Wirth T, et al. (1999). "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1". J. Biol. Chem. 274 (18): 12910–6. doi:10.1074/jbc.274.18.12910. PMID 10212281. 
• Van Esch H, Groenen P, Nesbit MA, et al. (2000). "GATA3 haplo-insufficiency causes human HDR syndrome". Nature 406 (6794): 419–22. doi:10.1038/35019088. PMID 10935639. 
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948. 
• Muroya K, Hasegawa T, Ito Y, et al. (2001). "GATA3 abnormalities and the phenotypic spectrum of HDR syndrome". J. Med. Genet. 38 (6): 374–80. doi:10.1136/jmg.38.6.374. PMC 1734904. PMID 11389161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1734904. 
• Crawford SE, Qi C, Misra P, et al. (2002). "Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors". J. Biol. Chem. 277 (5): 3585–92. doi:10.1074/jbc.M107995200. PMID 11724781. 
• Kieffer LJ, Greally JM, Landres I, et al. (2002). "Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3". J. Immunol. 168 (8): 3915–22. PMID 11937547. 
• Asnagli H, Afkarian M, Murphy KM (2002). "Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human". J. Immunol. 168 (9): 4268–71. PMID 11970965. 
• Steenbergen RD, OudeEngberink VE, Kramer D, et al. (2002). "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis". Am. J. Pathol. 160 (6): 1945–51. doi:10.1016/S0002-9440(10)61143-1. PMC 1850837. PMID 12057898. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850837. 
• Höfer T, Nathansen H, Löhning M, et al. (2002). "GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9364–8. doi:10.1073/pnas.142284699. PMC 123146. PMID 12087127. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=123146. 
• Karunaratne A, Hargrave M, Poh A, Yamada T (2002). "GATA proteins identify a novel ventral interneuron subclass in the developing chick spinal cord". Dev. Biol. 249 (1): 30–43. doi:10.1006/dbio.2002.0754. PMID 12217316. 

External links

• MeSH GATA3+protein,+human
• FactorBook GATA3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.