ATF7

Activating transcription factor 7
Identifiers
Symbols	ATF7; ATFA; MGC57182
External IDs	OMIM: 606371 MGI: 2443472 HomoloGene: 4994 GeneCards: ATF7 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding • protein dimerization activity Cellular component • intracellular • nucleus • nucleus • nucleoplasm • cytoplasm • nuclear periphery Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • regulation of transcription, DNA-dependent • interspecies interaction between organisms Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11016	223922
Ensembl	ENSG00000170653	ENSMUSG00000052414
UniProt	P17544	Q3TZR9
RefSeq (mRNA)	NM_001130059.1	NM_146065.1
RefSeq (protein)	NP_001123531.1	NP_666177.1
Location (UCSC)	Chr 12: 53.91 – 54.02 Mb	Chr 15: 102.36 – 102.46 Mb
PubMed search	[1]	[2]

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.

Homonym

In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1. This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• Hamard PJ, Dalbies-Tran R, Hauss C, et al. (2005). "A functional interaction between ATF7 and TAF12 that is modulated by TAF4". Oncogene 24 (21): 3472–83. doi:10.1038/sj.onc.1208565. PMID 15735663. 
• Hamard PJ, Boyer-Guittaut M, Camuzeaux B, et al. (2007). "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity". Nucleic Acids Res. 35 (4): 1134–44. doi:10.1093/nar/gkl1168. PMC 1851647. PMID 17264123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1851647. 
• Breitwieser W, Lyons S, Flenniken AM, et al. (2007). "Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells". Genes Dev. 21 (16): 2069–82. doi:10.1101/gad.430207. PMC 1948861. PMID 17699753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1948861. 
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Newman SP, Bates NP, Vernimmen D, et al. (2000). "Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer". Oncogene 19 (4): 490–7. doi:10.1038/sj.onc.1203416. PMID 10698518. 
• Goetz J, Chatton B, Mattei MG, Kedinger C (1997). "Structure and expression of the ATFa gene". J. Biol. Chem. 271 (47): 29589–98. doi:10.1074/jbc.271.47.29589. PMID 8939888. 
• Bocco JL, Bahr A, Goetz J, et al. (1996). "In vivo association of ATFa with JNK/SAP kinase activities". Oncogene 12 (9): 1971–80. PMID 8649858. 
• Pescini R, Kaszubska W, Whelan J, et al. (1994). "ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers". J. Biol. Chem. 269 (2): 1159–65. PMID 8288576. 
• Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30. PMC 189172. PMID 7769693. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=189172. 

External links

• MeSH ATF7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.