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From Wikipedia, the free encyclopedia
| Iroquois homeobox 3 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||
| Symbols | IRX3; FLJ99187; IRX-1; IRXB1 | |||||||
| External IDs | OMIM: 612985 MGI: 1197522 HomoloGene: 7385 GeneCards: IRX3 Gene | |||||||
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| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 79191 | 16373 | ||||||
| Ensembl | ENSG00000177508 | ENSMUSG00000031734 | ||||||
| UniProt | P78415 | P81067 | ||||||
| RefSeq (mRNA) | NM_024336 | NM_008393.2 | ||||||
| RefSeq (protein) | NP_077312 | NP_032419.2 | ||||||
| Location (UCSC) | Chr 16: 54.32 – 54.32 Mb |
Chr 8: 94.32 – 94.33 Mb |
||||||
| PubMed search | [1] | [2] |
Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.[1]
[edit] Function
IRX3 is a member of the Iroquois homeobox gene family and plays a role in an early step of neural development.[2] Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1][3]
[edit] References
- ^ a b "Entrez Gene: iroquois homeobox 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79191.
- ^ Bellefroid EJ, Kobbe A, Gruss P, Pieler T, Gurdon JB, Papalopulu N (January 1998). "Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification". EMBO J. 17 (1): 191–203. doi:10.1093/emboj/17.1.191. PMC 1170370. PMID 9427753. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170370.
- ^ Lewis MT, Ross S, Strickland PA, Snyder CJ, Daniel CW (June 1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.". Gut 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ragvin A, Moro E, Fredman D, et al. (2010). "Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.". Proc. Natl. Acad. Sci. U.S.A. 107 (2): 775–80. doi:10.1073/pnas.0911591107. PMID 20080751.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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