GPR35
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| G protein-coupled receptor 35 | ||||||||
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| Identifiers | ||||||||
| Symbol | GPR35 | |||||||
| External IDs | OMIM: 602646 MGI: 1929509 HomoloGene: 3874 IUPHAR: GPR35 ChEMBL: 1293267 GeneCards: GPR35 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 2859 | 64095 | ||||||
| Ensembl | ENSG00000178623 | ENSMUSG00000026271 | ||||||
| UniProt | Q9HC97 | Q9ES90 | ||||||
| RefSeq (mRNA) | NM_001195381.1 | NM_001104529.1 | ||||||
| RefSeq (protein) | NP_001182310.1 | NP_001097999.1 | ||||||
| Location (UCSC) | Chr 2: 241.54 – 241.57 Mb |
Chr 1: 92.97 – 92.99 Mb |
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| PubMed search | [1] | [2] | ||||||
G protein-coupled receptor 35 also known as GPR35 is a G protein-coupled receptor which in humans is encoded by the GPR35 gene[1] Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the crypts of Lieberkühn.
[edit] Ligands
One study has shown that kynurenic acid acts as an endogenous ligand for this receptor.[2] Zaprinast, a PDE5A inhibitor, was found to be an agonist for GPR35.[3]
[edit] Clinical significance
Deletion of GPR35 gene may be responsible for brachydactyly mental retardation syndrome and is mutated in 2q37 monosomy and 2q37 deletion syndrome.[4] In one study GPR35 has been recognised as a potential oncogene in the stomach cancer.[5]
[edit] References
- ^ O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR (1998). "Discovery of three novel G-protein-coupled receptor genes". Genomics 47 (2): 310–3. doi:10.1006/geno.1998.5095. PMID 9479505.
- ^ Wang J, Simonavicius N, Wu X, Swaminath G, Reagan J, Tian H, Ling L (2006). "Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35". J. Biol. Chem. 281 (31): 22021–8. doi:10.1074/jbc.M603503200. PMID 16754668.free fulltext
- ^ Taniguchi Y, Tonai-Kachi H, Shinjo K (2006). "Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35". FEBS Lett. 580 (21): 5003–8. doi:10.1016/j.febslet.2006.08.015. PMID 16934253.
- ^ Shrimpton AE, Braddock BR, Thomson LL, Stein CK, Hoo JJ (2004). "Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype". Clin. Genet. 66 (6): 537–44. doi:10.1111/j.1399-0004.2004.00363.x. PMID 15521982.
- ^ Okumura S, Baba H, Kumada T, Nanmoku K, Nakajima H, Nakane Y, Hioki K, Ikenaka K (2004). "Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells". Cancer Sci. 95 (2): 131–5. doi:10.1111/j.1349-7006.2004.tb03193.x. PMID 14965362.
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