GNRHR2

Gonadotropin-releasing hormone (type 2) receptor 2
Identifiers
Symbols	GNRHR2; GnRH-II-R
External IDs	OMIM: 612875 IUPHAR: GnRH2 receptor GeneCards: GNRHR2 Gene
Gene Ontology Molecular function • gonadotropin-releasing hormone receptor activity Cellular component • plasma membrane • integral to membrane Biological process • signal transduction • G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114814	n/a
Ensembl	ENSG00000211451	n/a
UniProt	Q96P88	n/a
RefSeq (mRNA)	NM_057163.2	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 1: 145.51 – 145.52 Mb	n/a
PubMed search	[1]	n/a

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.

Function

The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.

See also

• Gonadotropin-releasing hormone receptor

Further reading

• Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology 143 (3): 737–43. doi:10.1210/en.143.3.737. PMID 11861490.
• Millar R, Conklin D, Lofton-Day C, et al. (1999). "A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript". J. Endocrinol. 162 (1): 117–26. doi:10.1677/joe.0.1620117. PMID 10396028.
• Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates". Biochem. Biophys. Res. Commun. 282 (4): 1012–8. doi:10.1006/bbrc.2001.4678. PMID 11352653.
• van Biljon W, Wykes S, Scherer S, et al. (2003). "Type II gonadotropin-releasing hormone receptor transcripts in human sperm". Biol. Reprod. 67 (6): 1741–9. doi:10.1095/biolreprod.101.002808. PMID 12444048.
• Morgan K, Conklin D, Pawson AJ, et al. (2003). "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12". Endocrinology 144 (2): 423–36. doi:10.1210/en.2002-220622. PMID 12538601.
• Pawson AJ, Maudsley S, Morgan K, et al. (2005). "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology 146 (6): 2639–49. doi:10.1210/en.2005-0133. PMID 15761034.
• Eicke N, Günthert AR, Viereck V, et al. (2005). "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. doi:10.1530/eje.1.02005. PMID 16189182.
• Ikemoto T, Park MK (2006). "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics 87 (4): 459–62. doi:10.1016/j.ygeno.2005.11.005. PMID 16406723.
• Parker JD, Malik M, Catherino WH (2007). "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. doi:10.1016/j.fertnstert.2006.11.098. PMID 17296196.

External links

• "Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3212.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.