STAT6
From Wikipedia, the free encyclopedia
| Signal transducer and activator of transcription 6, interleukin-4 induced | ||||||||
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| Identifiers | ||||||||
| Symbols | STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C | |||||||
| External IDs | OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 6778 | 20852 | ||||||
| Ensembl | ENSG00000166888 | ENSMUSG00000002147 | ||||||
| UniProt | P42226 | P70383 | ||||||
| RefSeq (mRNA) | NM_001178078.1 | NM_009284.2 | ||||||
| RefSeq (protein) | NP_001171549.1 | NP_033310.2 | ||||||
| Location (UCSC) | Chr 12: 57.49 – 57.51 Mb |
Chr 10: 127.08 – 127.1 Mb |
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| PubMed search | [1] | [2] |
STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.[1][2]
In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.[3]
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[edit] Interactions
STAT6 has been shown to interact with EP300,[4] CREB-binding protein,[5][4] NFKB1,[6] Nuclear receptor coactivator 1,[5][7] IRF4[8] and SND1.[9]
[edit] See also
[edit] References
- ^ Leek JP, Hamlin PJ, Bell SM, Lench NJ (1997). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9. doi:10.1159/000134723. PMID 9605853.
- ^ Hou J, Schindler U, Henzel WJ, Ho TC, Brasseur M, McKnight SL (September 1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science 265 (5179): 1701–6. doi:10.1126/science.8085155. PMID 8085155. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8085155.
- ^ "Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6778.
- ^ a b McDonald, C; Reich N C (Jul. 1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". J. Interferon Cytokine Res. (UNITED STATES) 19 (7): 711–22. doi:10.1089/107999099313550. ISSN 1079-9907. PMID 10454341.
- ^ a b Litterst, C M; Pfitzner E (Dec. 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". J. Biol. Chem. (United States) 276 (49): 45713–21. doi:10.1074/jbc.M108132200. ISSN 0021-9258. PMID 11574547.
- ^ Shen, C H; Stavnezer J (Jun. 1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. (UNITED STATES) 18 (6): 3395–404. ISSN 0270-7306. PMC 108921. PMID 9584180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108921.
- ^ Litterst, Claudia M; Pfitzner Edith (Sep. 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". J. Biol. Chem. (United States) 277 (39): 36052–60. doi:10.1074/jbc.M203556200. ISSN 0021-9258. PMID 12138096.
- ^ Gupta, S; Jiang M, Anthony A, Pernis A B (Dec. 1999). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. (UNITED STATES) 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. ISSN 0022-1007. PMC 2195723. PMID 10601358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195723.
- ^ Yang, Jie; Aittomäki Saara, Pesu Marko, Carter Kara, Saarinen Jussi, Kalkkinen Nisse, Kieff Elliott, Silvennoinen Olli (Sep. 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. (England) 21 (18): 4950–8. doi:10.1093/emboj/cdf463. ISSN 0261-4189. PMC 126276. PMID 12234934. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126276.
[edit] Further reading
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
- Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges". Gene 285 (1–2): 1–24. doi:10.1016/S0378-1119(02)00398-0. PMID 12039028.
- Hou J, Schindler U, Henzel WJ, et al. (1994). "An interleukin-4-induced transcription factor: IL-4 Stat". Science 265 (5179): 1701–6. doi:10.1126/science.8085155. PMID 8085155.
- Takeda K, Tanaka T, Shi W, et al. (1996). "Essential role of Stat6 in IL-4 signalling". Nature 380 (6575): 627–30. doi:10.1038/380627a0. PMID 8602263.
- Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene". Nature 380 (6575): 630–3. doi:10.1038/380630a0. PMID 8602264.
- Kotanides H, Reich NC (1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene". J. Biol. Chem. 271 (41): 25555–61. doi:10.1074/jbc.271.41.25555. PMID 8810328.
- Mikita T, Campbell D, Wu P, et al. (1996). "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6". Mol. Cell. Biol. 16 (10): 5811–20. PMC 231582. PMID 8816495. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231582.
- Shen CH, Stavnezer J (1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription". Mol. Cell. Biol. 18 (6): 3395–404. PMC 108921. PMID 9584180. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108921.
- Leek JP, Hamlin PJ, Bell SM, Lench NJ (1998). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization". Cytogenet. Cell Genet. 79 (3–4): 208–9. doi:10.1159/000134723. PMID 9605853.
- Mikita T, Kurama M, Schindler U (1998). "Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta". J. Immunol. 161 (4): 1822–8. PMID 9712049.
- Patel BK, Keck CL, O'Leary RS, et al. (1998). "Localization of the human stat6 gene to chromosome 12q13.3-q14.1, a region implicated in multiple solid tumors". Genomics 52 (2): 192–200. doi:10.1006/geno.1998.5436. PMID 9782085.
- Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell 96 (1): 121–30. doi:10.1016/S0092-8674(00)80965-4. PMID 9989503.
- McDonald C, Reich NC (1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6". J. Interferon Cytokine Res. 19 (7): 711–22. doi:10.1089/107999099313550. PMID 10454341.
- Harris MB, Chang CC, Berton MT, et al. (2000). "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching". Mol. Cell. Biol. 19 (10): 7264–75. PMC 84719. PMID 10490661. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84719.
- Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells". J. Immunol. 163 (7): 3834–41. PMID 10490982.
- Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4". J. Exp. Med. 190 (12): 1837–48. doi:10.1084/jem.190.12.1837. PMC 2195723. PMID 10601358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195723.
- Daniel C, Salvekar A, Schindler U (2000). "A gain-of-function mutation in STAT6". J. Biol. Chem. 275 (19): 14255–9. doi:10.1074/jbc.C000129200. PMID 10747856.
- Arinobu Y, Sugimoto R, Akaiwa M, et al. (2000). "Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells". Biochem. Biophys. Res. Commun. 277 (2): 317–24. doi:10.1006/bbrc.2000.3674. PMID 11032724.
- Masuda A, Matsuguchi T, Yamaki K, et al. (2001). "Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression". J. Biol. Chem. 276 (28): 26107–13. doi:10.1074/jbc.M011475200. PMID 11369758.
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