COUP-TFII

Nuclear receptor subfamily 2, group F, member 2
Identifiers
Symbols	NR2F2; ARP1; COUPTFB; COUPTFII; MGC117452; NR2F1; SVP40; TFCOUP2
External IDs	OMIM: 107773 MGI: 1352452 HomoloGene: 7628 GeneCards: NR2F2 Gene
Gene Ontology Molecular function • retinoic acid binding • sequence-specific DNA binding transcription factor activity • ligand-regulated transcription factor activity • steroid hormone receptor activity • transcription corepressor activity • ligand-dependent nuclear receptor activity • protein binding • zinc ion binding • protein homodimerization activity • sequence-specific DNA binding • metal ion binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • neuron migration • negative regulation of endothelial cell proliferation • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • lipid metabolic process • signal transduction • skeletal muscle tissue development • anterior/posterior pattern formation • radial pattern formation • negative regulation of endothelial cell migration • forebrain development • response to estradiol stimulus • negative regulation of cyclin-dependent protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • blood vessel morphogenesis • limb development • regulation of transcription involved in lymphatic endothelial cell fate commitment Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7026	11819
Ensembl	ENSG00000185551	ENSMUSG00000030551
UniProt	P24468	Q3UST6
RefSeq (mRNA)	NM_001145155.1	NM_009697
RefSeq (protein)	NP_001138627.1	NP_033827
Location (UCSC)	Chr 15: 96.87 – 96.88 Mb	Chr 7: 77.5 – 77.51 Mb
PubMed search	[1]	[2]

COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene. The COUP acronym stands for chicken ovalbumin upstream promoter.

Function

COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.

The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity. COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.

Interactions

COUP-TFII has been shown to interact with:

• HDAC1
• Lck
• V-erbA-related gene.

Further reading

• De Martino MU, Alesci S, Chrousos GP, Kino T (2004). "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024: 72–85. doi:10.1196/annals.1321.006. PMID 15265774. 
• Mietus-Snyder M, Sladek FM, Ginsburg GS, et al. (1992). "Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells". Mol. Cell. Biol. 12 (4): 1708–18. PMC 369614. PMID 1312668. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369614. 
• Wang LH, Ing NH, Tsai SY, et al. (1992). "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207–16. PMID 1820218. 
• Ladias JA, Karathanasis SK (1991). "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily". Science 251 (4993): 561–5. doi:10.1126/science.1899293. PMID 1899293. 
• Marcus SL, Winrow CJ, Capone JP, Rachubinski RA (1996). "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. doi:10.1074/jbc.271.44.27197. PMID 8910285. 
• Thénot S, Henriquet C, Rochefort H, Cavaillès V (1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274. 
• Chu K, Zingg HH (1998). "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter". J. Mol. Endocrinol. 19 (2): 163–72. doi:10.1677/jme.0.0190163. PMID 9343308. 
• Bailey P, Sartorelli V, Hamamori Y, Muscat GE (1999). "The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD". Nucleic Acids Res. 26 (23): 5501–10. doi:10.1093/nar/26.23.5501. PMC 147985. PMID 9826778. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147985. 
• Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2823254. 
• Smirnov DA, Hou S, Ricciardi RP (2000). "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. doi:10.1006/viro.1999.0181. PMID 10704340. 
• Avram D, Fields A, Pretty On Top K, et al. (2000). "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2819356. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Jordan EM, Worley T, Breen GA (2003). "Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1". Biochemistry 42 (9): 2656–63. doi:10.1021/bi0268347. PMID 12614160. 
• Sato Y, Suzuki T, Hidaka K, et al. (2003). "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle". J. Clin. Endocrinol. Metab. 88 (7): 3415–20. doi:10.1210/jc.2002-021723. PMID 12843196. 
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kurihara I, Shibata H, Kobayashi S, et al. (2005). "Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription". J. Biol. Chem. 280 (8): 6721–30. doi:10.1074/jbc.M411820200. PMID 15611122. 
• Shibata H, Kobayashi S, Kurihara I, et al. (2005). "COUP-TF and transcriptional co-regulators in adrenal steroidogenesis". Endocr. Res. 30 (4): 795–801. doi:10.1081/ERC-200044042. PMID 15666827.