Galanin receptor 3
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| Galanin receptor 3 | ||||||||
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| Identifiers | ||||||||
| Symbols | GALR3; | |||||||
| External IDs | OMIM: 603692 MGI: 1329003 HomoloGene: 20798 IUPHAR: GAL3 GeneCards: GALR3 Gene | |||||||
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| RNA expression pattern | ||||||||
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| More reference expression data | ||||||||
| Orthologs | ||||||||
| Species | Human | Mouse | ||||||
| Entrez | 8484 | 14429 | ||||||
| Ensembl | ENSG00000128310 | ENSMUSG00000047429 | ||||||
| UniProt | O60755 | O88853 | ||||||
| RefSeq (mRNA) | NM_003614 | NM_015738.2 | ||||||
| RefSeq (protein) | NP_003605 | NP_056553.2 | ||||||
| Location (UCSC) | Chr 22: 38.22 – 38.22 Mb |
Chr 15: 78.87 – 78.87 Mb |
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| PubMed search | [1] | [2] |
Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1]
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1]
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[edit] See also
[edit] References
[edit] External links
- "Galanin Receptors: GAL3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2983.
[edit] Further reading
- Smith KE, Walker MW, Artymyshyn R, et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". J. Biol. Chem. 273 (36): 23321–6. doi:10.1074/jbc.273.36.23321. PMID 9722565.
- Kolakowski LF, O'Neill GP, Howard AD, et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". J. Neurochem. 71 (6): 2239–51. doi:10.1046/j.1471-4159.1998.71062239.x. PMID 9832121.
- Iismaa TP, Fathi Z, Hort YJ, et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes". Ann. N. Y. Acad. Sci. 863: 56–63. doi:10.1111/j.1749-6632.1998.tb10683.x. PMID 9928159.
- Lapsys NM, Furler SM, Henderson NK, et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Mol. Cell. Probes 13 (4): 325–7. doi:10.1006/mcpr.1999.0254. PMID 10441207.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Berger A, Tuechler C, Almer D, et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology 75 (2): 130–8. doi:10.1159/000048229. PMID 11867941.
- Belfer I, Hipp H, Bollettino A, et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333.
- Runesson J, Sollenberg UE, Jurkowski W, et al. (2010). "Determining receptor–ligand interaction of human galanin receptor type 3". Neurochem. Int. 57 (7): 804–811. doi:10.1016/j.neuint.2010.08.018. PMID 20817064.
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