GPR4

G protein-coupled receptor 4
Identifiers
Symbol	GPR4
External IDs	OMIM: 600551 MGI: 2441992 HomoloGene: 3867 IUPHAR: GPR4 GeneCards: GPR4 Gene
Gene Ontology Molecular function • G-protein coupled receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2828	319197
Ensembl	ENSG00000177464	ENSMUSG00000044317
UniProt	P46093	Q8BUD0
RefSeq (mRNA)	NM_005282.2	NM_175668.4
RefSeq (protein)	NP_005273.1	NP_783599.1
Location (UCSC)	Chr 19: 46.09 – 46.11 Mb	Chr 7: 19.21 – 19.22 Mb
PubMed search	[1]	[2]

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459.
• Heiber M, Docherty JM, Shah G et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
• Lum H, Qiao J, Walter RJ et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.
• Ludwig MG, Vanek M, Guerini D et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature 425 (6953): 93–8. doi:10.1038/nature01905. PMID 12955148.
• Bektas M, Barak LS, Jolly PS et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
• Sin WC, Zhang Y, Zhong W et al. (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007.
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. //www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
• Kim KS, Ren J, Jiang Y et al. (2005). "GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine". FASEB J. 19 (7): 819–21. doi:10.1096/fj.04-2988fje. PMID 15857892.
• Qiao J, Huang F, Naikawadi RP et al. (2006). "Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. doi:10.1152/ajplung.00508.2005. PMID 16461426.
• Huang F, Mehta D, Predescu S et al. (2007). "A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration". Endothelium 14 (1): 25–34. doi:10.1080/10623320601177288. PMID 17364894.
• Zou Y, Kim CH, Chung JH et al. (2007). "Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4". FEBS J. 274 (10): 2573–84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.
• Tobo M, Tomura H, Mogi C et al. (2007). "Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms". Cell. Signal. 19 (8): 1745–53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.