In the following Slitherlink, where you need to make one unbroken loop over the grid with the number in each cell matching the number of edges around that cell, I noticed that the 3-2-2-1 2x2 box at the middle top has only one possibility: the 1 having their right edge on as opposed to their bottom edge.
It's a quick deduction if you do trial and error using the bottom edge of the 1, as it quickly leads to contradiction on the top two cells.
But as trial and error method is typically not the first method one would use, I'm curious whether there are another way to deduce that the 1 should have the right edge on, instead of the bottom edge. My usual method of making an inaginary loop and counting edges (must be even) or even the latest trick I learned from this community about inside-outside don't seem to work 🤔
(Or otherwise, how to proceed in from this partially filled grid. I tried trial and error on the bottom left too, but ended up needing to resolve this section as well.)