The package implements the pathway activity signatures from LINCS data (pasLINCS) methodology for analysis of signaling pathways targeted by a perturbation. The paper describing the methodology can found here. The package is distributed under MIT open source license (see LICENSE file). The example code for using the package is provided in the Workflow_pasLINCS_UseCase.Rmd RStudio notebook. The knitted result of the notebook can be viewed here.

Step 0. Install "devtools" package. (Skip this step if "devtools" is already installed.)

install.packages("devtools")

Step 1. Install "paslincs" package.

library(devtools)
install_github("uc-bd2k/paslincs")

Please refer to the Workflow_pasLINCS_UseCase.Rmd RStudio notebook.