tweepy
An easy-to-use Python library for accessing the Twitter API.
Project Source: https://github.com/tweepy/tweepy
Project Homepage: http://www.tweepy.org/

twitter
Python Twitter API.
Project Source: https://github.com/sixohsix/twitter
Project Homepage: http://mike.verdone.ca/twitter/

twython
Actively maintained, pure Python wrapper for the Twitter API. Supports both normal and streaming Twitter APIs.
Project Source: https://github.com/ryanmcgrath/twython
Project Documentation: https://github.com/ryanmcgrath/twython

python-twitter
A Python wrapper around the Twitter API.
Project Source: https://github.com/bear/python-twitter
Project Documentation: https://dev.twitter.com/docs

facebook-sdk
A set of essential tools for working with Facebook in Python.
Project Source: https://github.com/pythonforfacebook/facebook-sdk
Project Homepage: http://www.pythonforfacebook.com/

pyfacebook
PyFacebook is a Python client library for the Facebook API.
Project Source: https://github.com/sciyoshi/pyfacebook

Django-facebook
Facebook open graph api implementation using the Django web framework in python.
Project Source: https://github.com/tschellenbach/Django-facebook
Project Homepage: http://www.mellowmorning.com/

Wikipedia
A Pythonic wrapper for the Wikipedia API.
Project Source: https://github.com/goldsmith/Wikipedia
Project Homepage: https://wikipedia.readthedocs.org/en/latest/

python-instagram
Python Client for Instagram API.
Project Source: https://github.com/Instagram/python-instagram

praw
A python package that allows for simple access to reddit's API.
Project Source: https://github.com/praw-dev/praw
Project Documentation: https://praw.readthedocs.org/en/v2.1.16/

PyAPNs
Python library for interacting with the Apple Push Notification service.
Project Source: https://github.com/djacobs/PyAPNs
Project Documentation: https://pypi.python.org/pypi/apns/

docker-py
An API client for docker written in Python.
Project Source: https://github.com/dotcloud/docker-py

PyGithub
Python library implementing the full GitHub API v3.
Project Source: https://github.com/jacquev6/PyGithub

sinaweibopy
Sina Weibo Python SDK.
Project Source: https://github.com/michaelliao/sinaweibopy
Project Homepage: http://github.liaoxuefeng.com/sinaweibopy/