I create makin to make initial malware assessment little bit easier for me, I think it's useful for others as well, It helps to reveal a debugger detection techniques used by a sample.

makin opens a sample as a debuggee and injects asho.dll(main module renames all dlls before injection), asho.dll hooks several functions at ntdll.dll and kernelbase.dll libraries and after parameters checkings, it sends the corresponding message to the debugger (makin.exe).

makin also generates a script for IDA Pro to set breakpoints at detected APIs.

At this moment, makin can reveal following techniques:

ntdll.dll:

• NtClose - ref: The "Ultimate" Anti-Debugging Reference: 7.B.ii
• NtOpenProcess - ref: The "Ultimate" Anti-Debugging Reference: 7.B.i
• NtCreateFile - ref: The "Ultimate" Anti-Debugging Reference: 7.B.iii (Open itself)
• NtCreateFile - ref: The "Ultimate" Anti-Debugging Reference: 7.B.iii (Open a driver)
• LdrLoadDll - ref: The "Ultimate" Anti-Debugging Reference: 7.B.iv
• NtSetDebugFilterState - ref: The "Ultimate" Anti-Debugging Reference: 7.D.vi
• NtQueryInformationProcess - ref: The "Ultimate" Anti-Debugging Reference: 7.D.viii.a, 7.D.viii.b, 7.D.viii.c
• NtQuerySystemInformation - ref: The "Ultimate" Anti-Debugging Reference: 7.E.iii
• NtSetInformationThread - ref: The "Ultimate" Anti-Debugging Reference 7.F.iii
• NtCreateUserProcess - ref: The "Ultimate" Anti-Debugging Reference 7.G.i
• NtCreateThreadEx - ref: ntuery blog post
• NtSystemDebugControl - ref: @waleedassar - pastebin
• NtYieldExecution - ref: The "Ultimate" Anti-Debugging Reference 7.D.xiii
• NtSetLdtEntries - ref: ANTI-UNPACKER TRICKS: PART ONE - 2.1.2
• NtQueryInformationThread - ref: ntquery - NtQueryInformationThread
• NtCreateDebugObject and NtQueryObject - ref: Anti-Debug NtQueryObject
• RtlAdjustPrivilege - ref: Using RtlAdjustPrivilege to detect debugger by insid3codeteam
• PEB->BeingDebugged - Instead of calling IsDebuggerPresent(), some programs manually check the PEB (Process Environment Block) for the BeingDebugged flag.
• PEB->NtGlobalFlag - ref: al-khaser
• UserSharedData->KdDebuggerEnabled - ref: al-khaser - SharedUserData_KernelDebugger
• Close PROCTECTED handle trick - ref: al-khaser - HANDLE_FLAG_PROTECT_FROM_CLOSE

kernelbase.dll:

• IsDebuggerPresent - ref: MSDN
• CheckRemoteDebuggerPresent - ref: MSDN
• SetUnhandledExceptionFilter - ref: The "Ultimate" Anti-Debugging Reference: D.xv
• RegOpenKeyExInternalW - checks registry keys
• RegQueryValueExW - checks registry key values

You can add more VM checks via editing checks.json file, without modification of the executable

That's all for now, you can add as much as you wish :)

• Zydis (MIT License)
• JSON for Modern C++ (MIT License)