Fish 44a5db4d1, which is builtin-path on top of b96c92a, also reproduces in 3.3.1:

bind \e suppress-autosuggestion cancel

will essentially break the arrow key bindings. This is because e.g. up-arrow sends \e\[A, and this already matches the \e and calls it done. Binding it with --preset works.

Presumably we're not looking across the lists?