aws-cli
Universal Command Line Interface for Amazon Web Services
Project Source: https://github.com/aws/aws-cli

boto
Boto is a Python package that provides interfaces to Amazon Web Services.
Project Source: https://github.com/boto/boto
Project Documentation: http://docs.pythonboto.org/en/latest/

dpark
DPark is a Python clone of Spark, MapReduce alike computing framework supporting iterative computation.
Project Source: https://github.com/douban/dpark
Project Documentation (Chinese): https://github.com/jackfengji/test_pro/wiki

dumbo
Python module that allows one to easily write and run Hadoop programs.
Project Source: https://github.com/klbostee/dumbo
Project Homepage: http://klbostee.github.io/dumbo/

Fabulous
Deploy django apps to Amazon EC2 with ONE command.
Project Source: https://github.com/gcollazo/Fabulous
Project Homepage: http://elweb.co/

falcon
Falcon is a high-performance Python framework for building cloud APIs and web app backends.
Project Source: https://github.com/racker/falcon
Project Homepage: http://falconframework.org/

gae-boilerplate
Google App Engine Boilerplate gets your project off the ground quickly using the Google App Engine platform.
Project Source: https://github.com/coto/gae-boilerplate
Project Homepage: http://appengine.beecoss.com/

goagent
a gae proxy
Project Source: https://github.com/goagent/goagent
Project Homepage: https://code.google.com/p/goagent/

Hue
Hue is an open source Web UI for doing big data with Hadoop.
Project Source: https://github.com/cloudera/hue
Project Homepage: http://gethue.com/

libcloud
Apache Libcloud is a Python library which hides differences between different cloud provider APIs and allows you to manage different cloud resources through a unified and easy to use API.
Project Source: https://github.com/apache/libcloud
Project Documentation: http://libcloud.apache.org/

mrjob
Run MapReduce jobs on Hadoop or Amazon Web Services.
Project Source: https://github.com/Yelp/mrjob
Project Documentation: https://pythonhosted.org/mrjob/

nova
OpenStack Nova provides a cloud computing fabric controller, supporting a wide variety of virtualization technologies, including KVM, Xen, LXC, VMware, and more.
Project Source: https://github.com/openstack/nova
Project Homepage: http://www.openstack.org/

pyes
pyes is a pythonic way to use ElasticSearch since 2010.
Project Source: https://github.com/aparo/pyes
Project Documentation: https://pypi.python.org/pypi/pyes/

s3cmd
Command line tool for managing Amazon S3 and CloudFront services.
Project Source: https://github.com/s3tools/s3cmd
Project Homepage: http://s3tools.org/s3cmd