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Transmembrane serine protease 2 (Q21126599)

From Wikidata

mammalian protein found in Homo sapiens

TMPRSS2
epitheliasin
serine protease 10
transmembrane protease serine 2
transmembrane protease, serine 2

Language	Label	Description	Also known as
default for all languages	No label defined	–
English	Transmembrane serine protease 2	mammalian protein found in Homo sapiens	TMPRSS2 epitheliasin serine protease 10 transmembrane protease serine 2 transmembrane protease, serine 2

Statements

1 reference

13 November 2019

UniProt protein ID

LDL receptor-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

peptidase S1A, chymotrypsin family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

Peptidase S1, PA clan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

SRCR-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

SRCR domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, histidine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

SRCR-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine proteases, trypsin family, serine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

scavenger receptor activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

peptidase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

protein binding

determination method or standard

1 reference

9 May 2019

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

hydrolase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

serine-type endopeptidase activity

determination method or standard

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

integral component of membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

extracellular region

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

extracellular exosome

determination method or standard

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15393&geneProductId=UniProtKB:O15393

determination method or standard

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15393&geneProductId=UniProtKB:O15393

determination method or standard

26 September 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15393&geneProductId=UniProtKB:O15393

determination method or standard

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15393&geneProductId=UniProtKB:O15393

determination method or standard

extracellular exosome

determination method or standard

3 references

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

biological process

positive regulation of viral entry into host cell

determination method or standard

2 references

9 May 2019

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

protein autoprocessing

determination method or standard

1 reference

26 September 2017

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15393&geneProductId=UniProtKB:O15393

determination method or standard

receptor-mediated endocytosis

determination method or standard

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

determination method or standard

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

9 May 2019

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

protein autoprocessing

determination method or standard

vesicle-mediated transport

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15393

determination method or standard

EC enzyme number

3.4.21.122

1 reference

UniProt protein ID

23 July 2026

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

serine proteases, trypsin family, histidine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

serine proteases, trypsin domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

low-density lipoprotein (LDL) receptor class A repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

SRCR-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

Serine proteases, trypsin family, serine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15393

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000330330

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000330330

ENSP00000381588

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000381588

ENSP00000391216

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391216

ENSP00000389006

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389006

ENSP00000391784

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000391784

ENSP00000397846

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397846

Guide to Pharmacology Target ID

1 reference

https://www.guidetopharmacology.org/coronavirus.jsp

22 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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