Neurosteroids: endogenous regulators of the GABAA receptor
- D. BelelliJ. Lambert
- 1 July 2005
Medicine, Chemistry
GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring…
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
- Valerie B. CaraiscosErin M. Elliott B. Orser
- 9 March 2004
Biology
The results suggest that tonic inhibition mediated by α5GABAARs in hippocampal pyramidal neurons plays a key role in cognitive processes.
Neurosteroids and GABAA receptor function.
- J. LambertD. BelelliC. Hill‐VenningJ. A. Peters
- 1 September 1995
Medicine
Neurosteroid modulation of GABAA receptors
- J. LambertD. BelelliD. PedenA. VardyJ. A. Peters
- 1 September 2003
Medicine, Biology
Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function
- D. BelelliN. HarrisonJ. MaguireR. MacdonaldM. WalkerD. Cope
- 14 October 2009
Medicine, Biology
This mini-symposium review highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents and identifies them as a major player in both physiological and pathophysiological processes.
Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics
- D. BelelliD. PedenT. RosahlK. WaffordJ. Lambert
- 14 December 2005
Medicine
Among hypnotic agents that enhance GABAA receptor function, etomidate is unusual because it is selective for β2/β3 compared with β1 subunit-containing GABAA receptors. Mice incorporating an…
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.
- Valerie B. CaraiscosErin M. Elliott B. Orser
- 2004
Biology
The results suggest that tonic inhibition mediated by alpha5GABA(A)Rs in hippocampal pyramidal neurons plays a key role in cognitive processes.
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.
- D. BelelliJ. LambertJ. A. PetersK. WaffordP. Whiting
- 30 September 1997
Medicine, Chemistry
The effects of a clinically utilized general anesthetic upon a physiologically relevant target protein are dramatically influenced by a single amino acid, and the data argue against a unitary, lipid-based theory of anesthesia.
The influence of subunit composition on the interaction of neurosteroids with GABAA receptors
- D. BelelliA. CasulaAlice LingJ. Lambert
- 1 September 2002
Biology, Chemistry
Dysfunctional Astrocytic and Synaptic Regulation of Hypothalamic Glutamatergic Transmission in a Mouse Model of Early-Life Adversity: Relevance to Neurosteroids and Programming of the Stress Response
- B. GunnL. Cunningham D. Belelli
- 11 December 2013
Biology, Medicine
It is revealed that increased synaptic and tonic glutamatergic transmission may be a common maladaptation to ELS, leading to enhanced excitation of CRF-releasing neurons, and identifies neurosteroids as putative early regulators of the stress neurocircuitry.
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