Influence of Postweaning Social Isolation in the Rat on Brain Development, Conditioned Behavior, and Neurotransmission
- M. LapizA. FulfordS. MuchimapuraR. MasonT. ParkerC. Marsden
- 2004
Biology, Psychology
The effects of rearing rats from weaning in social isolation are reviewed and some recent results indicating hippocampal dysfunction are reported, which should improve knowledge of how environmental events may alter brain development and function, and play a role in the development of neuropsychiatric disorders.
The nociceptin receptor antagonist [Nphe1,Arg14,Lys15]nociceptin/orphanin FQ-NH2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats
- J. LeggettM. HarbuzD. S. JessopA. Fulford
- 31 December 2006
Biology, Medicine
Regulation of nociceptin/orphaninFQ secretion by immune cells and functional modulation of interleukin-2
- T. MillerA. Fulford
- 1 November 2007
Biology, Medicine
Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat
- A. FulfordC. A. Marsden
- 31 December 1998
Biology, Psychology
Nociceptin/orphanin FQ modulates human T cell function in vitro
- P. WaitsW. PurcellA. FulfordJ. McLeod
- 1 April 2004
Biology, Medicine
Endogenous Nociceptin / Orphanin FQ System Involvement in Hypothalamic-Pituitary-Adrenal Axis Responses: Relevance to Models of Inflammation
- J. LeggettK. DaweD. JessopA. Fulford
- 1 November 2009
Biology, Medicine
Evidence is provided indicating that the endogenous NOP system is involved in the acute HPA axis response to immune challenge, and LPS was associated with a significant attenuation of NOP mRNA in the basal forebrain at 4 h, possibly as a compensatory response to increased N/OFQ release.
Effect of Isolation‐Rearing on Conditioned Dopamine Release In Vivo in the Nucleus Accumbens of the Rat
- A. FulfordC. Marsden
- 1 January 1998
Biology, Psychology
Abstract: Intracerebral microdialysis in conjunction with HPLC coupled to electrochemical detection was used to investigate the effect of isolation‐rearing in the rat on extracellular dopamine (DA)…
Role of Nociceptin/Orphanin FQ and NOP Receptors in the Response to Acute and Repeated Restraint Stress in Rats
- G. DelaneyK. Dawe A. Fulford
- 20 November 2012
Biology, Medicine
It is confirmed that the significant role of endogenous NOP receptors and tonic N/OFQ function in the response to the psychological stress of restraint is confirmed, and an endogenous role for central N/ OFQ in psychological stress is supported.
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