SLC25A24

SLC34A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N5X, 4ZCU, 4ZCV
Identifiers
Aliases	SLC34A1, FRTS2, NAPI-3, NPHLOP1, NPT2, NPTIIa, SLC11, SLC17A2, solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24, APC1, SCAMC-1, SLC25A24, solute carrier family 25 member 24, solute carrier family 34 member 1, HCINF2
External IDs	MGI: 1345284 HomoloGene: 20663 GeneCards: SLC34A1
Gene ontology Molecular function • PDZ domain binding • protein homodimerization activity • protein complex binding • protein binding • symporter activity • sodium:phosphate symporter activity • sodium-dependent phosphate transmembrane transporter activity • calcium ion binding • ATP transmembrane transporter activity • metal ion binding • ADP transmembrane transporter activity Cellular component • integral component of membrane • endosome • membrane • intrinsic component of plasma membrane • integral component of plasma membrane • cell surface • brush border membrane • perinuclear region of cytoplasm • membrane raft • vesicle • brush border • cytoplasm • plasma membrane • apical plasma membrane • mitochondrion • mitochondrial inner membrane Biological process • cellular protein metabolic process • phosphate ion transport • response to potassium ion • response to estradiol • cellular response to staurosporine • glycoprotein metabolic process • response to cadmium ion • ossification • sodium-dependent phosphate transport • positive regulation of phosphate transmembrane transport • kidney development • response to nutrient • sodium ion transport • response to thyroid hormone • response to peptide hormone • phosphate ion homeostasis • response to magnesium ion • dentinogenesis • response to peptide • response to vitamin A • indole metabolic process • cellular response to metal ion • response to parathyroid hormone • response to lead ion • tricarboxylic acid metabolic process • gentamycin metabolic process • response to growth hormone • transport • arsenate ion transmembrane transport • response to mercury ion • cellular response to parathyroid hormone stimulus • positive regulation of sodium-dependent phosphate transport • positive regulation of membrane potential • protein homooligomerization • response to drug • phosphate ion transmembrane transport • cellular phosphate ion homeostasis • sodium ion transmembrane transport • ion transport • regulation of cell death • cellular response to calcium ion • cellular response to oxidative stress • mitochondrial transport • transmembrane transport • ATP transport • ADP transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6569	20505
Ensembl	ENSG00000131183	ENSMUSG00000021490
UniProt	Q06495 Q7Z725 Q6NUK1	Q60825 Q9D2V6
RefSeq (mRNA)	NM_001167579 NM_003052	NM_011392
RefSeq (protein)	NP_001161051 NP_003043 NP_003043.3 NP_037518 NP_998816	NP_035522
Location (UCSC)	Chr 5: 177.38 – 177.4 Mb	Chr 13: 55.4 – 55.41 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 is a protein that in humans is encoded by the SLC25A24 gene.

Function

This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Fiermonte G, De Leonardis F, Todisco S, Palmieri L, Lasorsa FM, Palmieri F (July 2004). "Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution". The Journal of Biological Chemistry. 279 (29): 30722–30. doi:10.1074/jbc.M400445200. PMID 15123600. 
• del Arco A, Satrústegui J (June 2004). "Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains". The Journal of Biological Chemistry. 279 (23): 24701–13. doi:10.1074/jbc.M401417200. PMID 15054102. 
• Traba J, Del Arco A, Duchen MR, Szabadkai G, Satrústegui J (April 2012). "SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981 . PMID 22015608. 
• Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology". Molecular Aspects of Medicine. 34 (2-3): 465–84. doi:10.1016/j.mam.2012.05.005. PMID 23266187. 
• Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (January 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.