Norelgestromin
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| Trade names | Evra, Ortho Evra |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a602006 |
| Routes of administration |
Transdermal patch |
| ATC code | G03AA13 (WHO) (only combinations with estrogens) |
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| Identifiers | |
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| Synonyms | 17-Deacetylnorgestimate, levonorgestrel 3-oxime |
| CAS Number | 53016-31-2  |
| PubChem (CID) | 62930 |
| DrugBank | DB06713  |
| ChemSpider | 56648 |
| UNII | R0TAY3X631 |
| KEGG | D05205 |
| ChEBI | CHEBI:111762 |
| ChEMBL | CHEMBL1200807 |
| Chemical and physical data | |
| Formula | C21H29NO2 |
| Molar mass | 327.461 g/mol |
| 3D model (Jmol) | Interactive image |
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Norelgestromin (INN, USAN, BAN), or norelgestromine, also known as 17-deacetylnorgestimate or norgestrel 3-oxime,[1] is a steroidal progestin of the 19-nortestosterone group used in the contraceptive patch called Evra or Ortho Evra, where it is combined with the estrogen ethinylestradiol.[2][3] It is one of the active metabolites of norgestimate.[4][5] Unlike many other 19-nortestosterone derivatives, norelgestromin has negligible androgenic activity.[5] The drug was introduced in 2002.[6]
References[edit]
- ^ IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; World Health Organization; International Agency for Research on Cancer (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. pp. 150–151. ISBN 978-92-832-1291-1.
- ^ Drugs.com: Norelgestromin/Ethinyl Estradiol Patch
- ^ Crosignani, Pier Giorgio; Nappi, Carmine; Ronsini, Salvatore; Bruni, Vincenzina; Marelli, Silvia; Sonnino, Davide (2009). "Satisfaction and compliance in hormonal contraception: the result of a multicentre clinical study on women's experience with the ethinylestradiol/norelgestromin contraceptive patch in Italy". BMC Women's Health. 9 (1): 18. doi:10.1186/1472-6874-9-18. ISSN 1472-6874. PMC 2714834
. PMID 19566925. - ^ Annette M. Doherty (2003). Annual Reports in Medicinal Chemistry. Academic Press. pp. 362–. ISBN 978-0-12-040538-1.
- ^ a b Stefan Offermanns; Walter Rosenthal (14 August 2008). Encyclopedia of Molecular Pharmacology. Springer Science & Business Media. pp. 391–. ISBN 978-3-540-38916-3.
- ^ John E. Macor (2012). Annual Reports in Medicinal Chemistry. Academic Press. pp. 620–. ISBN 978-0-12-396492-2.
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