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Hey2 Gene Detail
Summary
  • Symbol
    Hey2
  • Name
    hairy/enhancer-of-split related with YRPW motif 2
  • Synonyms
    bHLHb32, CHF1, Herp1, Hesr2, Hrt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341884
    NCBI Gene: 15214
  • Gene Overview
    MyGene.info: HEY2
Location & Maps
more
  • Sequence Map
    Chr10:30832359-30842801 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10443 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 17.19 cM, cytoband A4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    HEY2, hes related family bHLH transcription factor with YRPW motif 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHb32, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2
  • Links
    NCBI Gene ID: 23493
    neXtProt AC: NX_Q9UBP5

  • Chr Location
    6q21; chr6:125749586-125761271 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 22705
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HEY2
  • Gene Tree
    Hey2
Human Diseases
more
  • Diseases
    1 with Hey2 mouse models

Human Disease Mouse Models
       Tetralogy of Fallot; TOF   OMIM: 187500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 7 alleles in 14 genetic backgrounds
    34 phenotypes from multigenic genotypes
    4 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Targeted
    10
  • Genomic Mutations
    1 involving Hey2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Homozygotes for targeted null mutations exhibit cardiac hypertrophy, ventricular septal defects, pulmonary and liver congestion, and reduced preweaning viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    399
  • Tissues
    243
  • cDNA Data
    26
  • Literature Summary
    127
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000038103 VEGA Gene Model | MGI Sequence Detail 10443 C57BL/6J ±  kb
transcript OTTMUST00000098167 VEGA | MGI Sequence Detail 2550 Not Applicable  
polypeptide OTTMUSP00000055117 VEGA | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    59 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008529 hairy/enhancer-of-split related with YRPW motif protein 2
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
less
  • All nucleic 35
    cDNA 26
    Primer pair 5
    Other 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:1353481
References
more
  • Summaries
    All 179
    Developmental Gene Expression 127
    Diseases 1
    Gene Ontology 31
    Phenotypes 37
  • Earliest
    J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
  • Latest
    J:231532 Lange C, et al., Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J. 2016 May 2;35(9):924-41
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/09/2016
MGI 6.05 		The Jackson Laboratory
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