Apronal
From Wikipedia, the free encyclopedia
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| Systematic (IUPAC) name | |
|---|---|
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(±)-N-Carbamoyl-2-propan-2-ylpent-4-enamide
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| Clinical data | |
| Routes of administration |
Oral |
| Pharmacokinetic data | |
| Excretion | Renal |
| Identifiers | |
| CAS Number | 528-92-7  |
| ATC code | N05CM12 (WHO) |
| PubChem | CID 10715 |
| ChemSpider | 10264 |
| UNII | V18J24E25E |
| KEGG | D03975 |
| ChEMBL | CHEMBL509282 |
| Chemical data | |
| Formula | C9H16N2O2 |
| Molar mass | 184.236 g/mol |
| Chirality | Racemic mixture |
| 3D model (Jmol) | Interactive image |
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Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926[1] by Hoffmann-La Roche that is no longer used. Though it is not a barbiturate, apronalide is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring).[2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours).[2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronalide was withdrawn from clinical use.[3]
See also[edit]
References[edit]
- ^ DE Patent 459903 - Verfahren zur Darstellung von Ureiden der Dialkylessigsaeuren
- ^ a b Roche Review ... Hoffman-La Roche, and Roche-organon. 1938. p. 164.
- ^ R. L. Vollum; D. G. Jamison; C. S. Cummins (20 May 2014). Fairbrother's Textbook of Bacteriology. Elsevier Science. pp. 152–. ISBN 978-1-4831-4178-7.
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