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Title:
The snoRNA HBII-52 Regulates Alternative Splicing of the Serotonin Receptor 2C
Authors:
Kishore, Shivendra; Stamm, Stefan
Publication:
Science, Volume 311, Issue 5758, pp. 230-232 (2006). (Sci Homepage)
Publication Date:
01/2006
Category:
MEDICINE
Origin:
SCIENCE
Abstract Copyright:
(c) 2006: Science
DOI:
10.1126/science.1118265
Bibliographic Code:
2006Sci...311..230K

Abstract

The Prader-Willi syndrome is a congenital disease that is caused by the loss of paternal gene expression from a maternally imprinted region on chromosome 15. This region contains a small nucleolar RNA (snoRNA), HBII-52, that exhibits sequence complementarity to the alternatively spliced exon Vb of the serotonin receptor 5-HT2CR. We found that HBII-52 regulates alternative splicing of 5-HT2CR by binding to a silencing element in exon Vb. Prader-Willi syndrome patients do not express HBII-52. They have different 5-HT2CR messenger RNA (mRNA) isoforms than healthy individuals. Our results show that a snoRNA regulates the processing of an mRNA expressed from a gene located on a different chromosome, and the results indicate that a defect in pre-mRNA processing contributes to the Prader-Willi syndrome.
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